TY - JOUR
T1 - Association of e-cadherin (CDH1) gene polymorphisms and gastric cancer risk
AU - al-Moundhri, Mansour S.
AU - al-Khanbashi, Manal
AU - al-Kindi, Mohammed
AU - al-Nabhani, Maryam
AU - Burney, Ikram A.
AU - al-Farsi, Abdulaziz
AU - al-Bahrani, Bassim
PY - 2010/7/21
Y1 - 2010/7/21
N2 - AIM: To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. METHODS: We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing. RESULTS: CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance. CONCLUSION: The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.
AB - AIM: To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. METHODS: We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing. RESULTS: CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance. CONCLUSION: The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.
KW - Cdh1
KW - Gastric cancer
KW - Polymorphism
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U2 - 10.3748/wjg.v16.i27.3432
DO - 10.3748/wjg.v16.i27.3432
M3 - Article
C2 - 20632448
AN - SCOPUS:77954848903
SN - 1007-9327
VL - 16
SP - 3432
EP - 3436
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 27
ER -
