Association of e-cadherin (CDH1) gene polymorphisms and gastric cancer risk

Mansour S. al-Moundhri, Manal al-Khanbashi, Mohammed al-Kindi, Maryam al-Nabhani, Ikram A. Burney, Abdulaziz al-Farsi, Bassim al-Bahrani

Research output: Contribution to journalArticle

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Abstract

AIM: To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. METHODS: We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing. RESULTS: CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance. CONCLUSION: The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.

Original languageEnglish
Pages (from-to)3432-3436
Number of pages5
JournalWorld Journal of Gastroenterology
Volume16
Issue number27
DOIs
Publication statusPublished - Jul 21 2010

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Cadherins
Stomach Neoplasms
Genes
Genotype
Haplotypes
Oman
Metagenomics
DNA Sequence Analysis
DNA

Keywords

  • Cdh1
  • Gastric cancer
  • Polymorphism

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Association of e-cadherin (CDH1) gene polymorphisms and gastric cancer risk. / al-Moundhri, Mansour S.; al-Khanbashi, Manal; al-Kindi, Mohammed; al-Nabhani, Maryam; Burney, Ikram A.; al-Farsi, Abdulaziz; al-Bahrani, Bassim.

In: World Journal of Gastroenterology, Vol. 16, No. 27, 21.07.2010, p. 3432-3436.

Research output: Contribution to journalArticle

al-Moundhri, MS, al-Khanbashi, M, al-Kindi, M, al-Nabhani, M, Burney, IA, al-Farsi, A & al-Bahrani, B 2010, 'Association of e-cadherin (CDH1) gene polymorphisms and gastric cancer risk', World Journal of Gastroenterology, vol. 16, no. 27, pp. 3432-3436. https://doi.org/10.3748/wjg.v16.i27.3432
al-Moundhri, Mansour S. ; al-Khanbashi, Manal ; al-Kindi, Mohammed ; al-Nabhani, Maryam ; Burney, Ikram A. ; al-Farsi, Abdulaziz ; al-Bahrani, Bassim. / Association of e-cadherin (CDH1) gene polymorphisms and gastric cancer risk. In: World Journal of Gastroenterology. 2010 ; Vol. 16, No. 27. pp. 3432-3436.
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