Agonists and antagonists for purinergic receptors

Christa E. Müller*, Younis Baqi, Vigneshwaran Namasivayam

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)


Membrane receptors that are activated by the purine nucleoside adenosine (adenosine receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce extracellular signals to the cytosol. They play important roles in physiology and disease. The G protein-coupled adenosine receptors comprise four subtypes: A1, A2A, A2B, and A3. The G-protein-coupled P2Y receptors are subdivided into eight subtypes: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, while the P2X receptors represent ATP-gated homomeric or heteromeric ion channels consisting of three subunits; the most important subunits are P2X1, P2X2, P2X3, P2X4, and P2X7. This chapter provides guidance for selecting suitable tool compounds for studying these large and important purine receptor families.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages20
Publication statusPublished - 2020

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Adenosine receptors
  • Agonists
  • Allosteric modulators
  • Antagonists
  • Binding site
  • Ligands
  • P2X receptors
  • P2Y receptors
  • Purine receptors
  • Structure
  • Tool compounds

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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