Abstract
Prognostic studies of T-cell lymphoblastic leukemia/lymphoma (T-ALL) have been performed in small patient cohorts with conflicting results. We systematically reviewed 67 adult T-ALL patients diagnosed and treated at our institute to identify clinical and pathologic prognostic factors. The median initial WBC was 21.3 × 109/l. Blasts expressed at least one myeloid-associated antigen in 33%. Karyotypes were abnormal in 32% of the cases. Fifty-six of 64 patients (88%) achieved complete remission (CR). In univariate analysis, age, gender, initial WBC, CD10, CD34 and abnormal karyotype did not predict CR. Patients expressing at least one myeloid-associated antigen had a CR of 74% compared to 94% (p = 0.04) for those not expressing myeloid antigens. None of the above factors affected relapse-free or overall survival in this cohort. Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy.
Original language | English |
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Pages (from-to) | 5-10 |
Number of pages | 6 |
Journal | Acta Haematologica |
Volume | 120 |
Issue number | 1 |
DOIs | |
Publication status | Published - Oct 2008 |
Externally published | Yes |
Keywords
- Adult T-lymphoblastic leukemia/lymphoma
- Cytogenetics
- Immunophenotype
- Lymphoblastic leukemia/lymphoma, prognosis
- Myeloid-associated antigens
ASJC Scopus subject areas
- Hematology