Abstract
Prognostic studies of T-cell lymphoblastic leukemia/lymphoma (T-ALL) have been performed in small patient cohorts with conflicting results. We systematically reviewed 67 adult T-ALL patients diagnosed and treated at our institute to identify clinical and pathologic prognostic factors. The median initial WBC was 21.3 × 109/l. Blasts expressed at least one myeloid-associated antigen in 33%. Karyotypes were abnormal in 32% of the cases. Fifty-six of 64 patients (88%) achieved complete remission (CR). In univariate analysis, age, gender, initial WBC, CD10, CD34 and abnormal karyotype did not predict CR. Patients expressing at least one myeloid-associated antigen had a CR of 74% compared to 94% (p = 0.04) for those not expressing myeloid antigens. None of the above factors affected relapse-free or overall survival in this cohort. Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 5-10 |
| Number of pages | 6 |
| Journal | Acta Haematologica |
| Volume | 120 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 2008 |
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Keywords
- Adult T-lymphoblastic leukemia/lymphoma
- Cytogenetics
- Immunophenotype
- Lymphoblastic leukemia/lymphoma, prognosis
- Myeloid-associated antigens
ASJC Scopus subject areas
- Hematology
Cite this
Adult Precursor T-Lymphoblastic Leukemia/Lymphoma with Myeloid-Associated Antigen Expression Is Associated with a Lower Complete Remission Rate following Induction Chemotherapy. / Al Khabori, Murtadha; Samiee, Samira; Fung, Sharon; Xu, Wei; Brandwein, Joseph; Patterson, Bruce; Brien, William; Chang, Hong.
In: Acta Haematologica, Vol. 120, No. 1, 10.2008, p. 5-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adult Precursor T-Lymphoblastic Leukemia/Lymphoma with Myeloid-Associated Antigen Expression Is Associated with a Lower Complete Remission Rate following Induction Chemotherapy
AU - Al Khabori, Murtadha
AU - Samiee, Samira
AU - Fung, Sharon
AU - Xu, Wei
AU - Brandwein, Joseph
AU - Patterson, Bruce
AU - Brien, William
AU - Chang, Hong
PY - 2008/10
Y1 - 2008/10
N2 - Prognostic studies of T-cell lymphoblastic leukemia/lymphoma (T-ALL) have been performed in small patient cohorts with conflicting results. We systematically reviewed 67 adult T-ALL patients diagnosed and treated at our institute to identify clinical and pathologic prognostic factors. The median initial WBC was 21.3 × 109/l. Blasts expressed at least one myeloid-associated antigen in 33%. Karyotypes were abnormal in 32% of the cases. Fifty-six of 64 patients (88%) achieved complete remission (CR). In univariate analysis, age, gender, initial WBC, CD10, CD34 and abnormal karyotype did not predict CR. Patients expressing at least one myeloid-associated antigen had a CR of 74% compared to 94% (p = 0.04) for those not expressing myeloid antigens. None of the above factors affected relapse-free or overall survival in this cohort. Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy.
AB - Prognostic studies of T-cell lymphoblastic leukemia/lymphoma (T-ALL) have been performed in small patient cohorts with conflicting results. We systematically reviewed 67 adult T-ALL patients diagnosed and treated at our institute to identify clinical and pathologic prognostic factors. The median initial WBC was 21.3 × 109/l. Blasts expressed at least one myeloid-associated antigen in 33%. Karyotypes were abnormal in 32% of the cases. Fifty-six of 64 patients (88%) achieved complete remission (CR). In univariate analysis, age, gender, initial WBC, CD10, CD34 and abnormal karyotype did not predict CR. Patients expressing at least one myeloid-associated antigen had a CR of 74% compared to 94% (p = 0.04) for those not expressing myeloid antigens. None of the above factors affected relapse-free or overall survival in this cohort. Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy.
KW - Adult T-lymphoblastic leukemia/lymphoma
KW - Cytogenetics
KW - Immunophenotype
KW - Lymphoblastic leukemia/lymphoma, prognosis
KW - Myeloid-associated antigens
UR - http://www.scopus.com/inward/record.url?scp=54249162407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54249162407&partnerID=8YFLogxK
U2 - 10.1159/000146081
DO - 10.1159/000146081
M3 - Article
C2 - 18635939
AN - SCOPUS:54249162407
VL - 120
SP - 5
EP - 10
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 1
ER -