Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)

for the ICLPS Investigators

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Abstract

Background: Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods: This cross-sectional observational study was conducted in 452 centres (August 2015−August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients (n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results: The mean±SD age was 60.2 ± 11.7 years, 55.0% of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions: These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.

Original languageEnglish
Pages (from-to)1087-1094
Number of pages8
JournalEuropean Journal of Preventive Cardiology
Volume25
Issue number10
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Practice Management
LDL Cholesterol
Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipids
Therapeutics
Physiological Sexual Dysfunctions
Eastern Europe
Middle East
Far East
Latin America
Observational Studies
Obesity
Cross-Sectional Studies
Smoking
Hypertension

Keywords

  • Cholesterol
  • guidelines
  • lipids
  • observational study
  • statins

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{fd1ea356ff0f40a19873539050f2e306,
title = "Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)",
abstract = "Background: Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods: This cross-sectional observational study was conducted in 452 centres (August 2015−August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients (n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results: The mean±SD age was 60.2 ± 11.7 years, 55.0{\%} of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9{\%} of patients were receiving a statin (25.3{\%} on high intensity treatment). Only 32.1{\%} of the very high risk patients versus 51.9{\%} of the high risk and 55.7{\%} of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions: These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.",
keywords = "Cholesterol, guidelines, lipids, observational study, statins",
author = "{for the ICLPS Investigators} and Nicolas Danchin and Wael Almahmeed and {Al Rasadi}, Khalid and Joseph Azuri and Abdelkrim Berrah and Cuneo, {Carlos Alberto} and Yuri Karpov and Upendra Kaul and Meral Kayık{\cc}ıoğlu and Olena Mitchenko and Ruiz, {Alvaro J.} and {Aguilar Salinas}, {Carlos A.} and Santos, {Raul D.} and Florence Mercier and Dirk Blom",
year = "2018",
month = "7",
day = "1",
doi = "10.1177/2047487318777079",
language = "English",
volume = "25",
pages = "1087--1094",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications Ltd",
number = "10",

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TY - JOUR

T1 - Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe

T2 - The International ChoLesterol management Practice Study (ICLPS)

AU - for the ICLPS Investigators

AU - Danchin, Nicolas

AU - Almahmeed, Wael

AU - Al Rasadi, Khalid

AU - Azuri, Joseph

AU - Berrah, Abdelkrim

AU - Cuneo, Carlos Alberto

AU - Karpov, Yuri

AU - Kaul, Upendra

AU - Kayıkçıoğlu, Meral

AU - Mitchenko, Olena

AU - Ruiz, Alvaro J.

AU - Aguilar Salinas, Carlos A.

AU - Santos, Raul D.

AU - Mercier, Florence

AU - Blom, Dirk

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods: This cross-sectional observational study was conducted in 452 centres (August 2015−August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients (n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results: The mean±SD age was 60.2 ± 11.7 years, 55.0% of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions: These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.

AB - Background: Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods: This cross-sectional observational study was conducted in 452 centres (August 2015−August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients (n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results: The mean±SD age was 60.2 ± 11.7 years, 55.0% of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions: These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.

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KW - guidelines

KW - lipids

KW - observational study

KW - statins

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