A profile of childhood neuropathies at a University Hospital in Oman

Roshan Koul, Alexander Chacko, Hashim Javed, Khalid Al-Hinai, Matthew Zachariah, Srinivas Bulusu, Thirapathur V. Rao

Research output: Contribution to journalArticle

Abstract

Objective: To analyze all cases of childhood neuropathies (under 14 years of age) and report on their profile, pattern, clinical features and management. Methods: Children with acute flaccid paralysis, longstanding weakness of extremities, neuroregression and children receiving anti cancer drugs with symptoms suggestive of neuropathy were evaluated for evidence of peripheral neuropathy. The evaluation of children with acute flaccid paralysis was a prospective study from January 1992 through to December 2000. The rest of the patients were studied retrospectively from the hospital medical records, pediatric neurology outpatient clinic and the neurophysiology laboratory, Sultan Qaboos University Hospital, Al-Khod, Oman. Results: Eighty-two (39 Male: 43 Female) children were found to have peripheral neuropathy. Acute Guillain-Barre syndrome was the most common with 37 children (45.1%), followed by genetic neuropathies [hereditary motor and sensory neuropathy with 17 (20.7%), hereditary sensory and autonomic neuropathy with 2 (2.4%), hereditary spastic paraplegia associated neuropathy with 9 (11%) and metachromatic leucodystrophy with 9 (11%)]. Chronic inflammatory demyelinating neuropathy was seen in 5 (6.1%) and vincristine induced neuropathy in 3 (3.5%) children. Conclusion: Acute Guillain-Barre syndrome is the most common neuropathy amongst the acquired neuropathies. The treatable neuropathies constituted 54.7% (45 children) and the preventable genetic neuropathies accounted for the remaining 45.3% (37 children).

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalNeurosciences
Volume7
Issue number2
Publication statusPublished - Apr 2002

Fingerprint

Oman
Guillain-Barre Syndrome
Peripheral Nervous System Diseases
Paralysis
Hereditary Sensory and Autonomic Neuropathies
Hereditary Sensory and Motor Neuropathy
Hereditary Spastic Paraplegia
Metachromatic Leukodystrophy
Neurophysiology
Hospital Records
Vincristine
Neurology
Ambulatory Care Facilities
Medical Records
Extremities
Prospective Studies
Pediatrics

Keywords

  • Childhood neuropathies
  • Chronic inflammatory demyelinating neuropathy
  • Guillain-Barre syndrome
  • Hereditary neuropathies
  • Metachromatic leucodystrophy
  • Prognosis
  • Toxic neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Koul, R., Chacko, A., Javed, H., Al-Hinai, K., Zachariah, M., Bulusu, S., & Rao, T. V. (2002). A profile of childhood neuropathies at a University Hospital in Oman. Neurosciences, 7(2), 92-98.

A profile of childhood neuropathies at a University Hospital in Oman. / Koul, Roshan; Chacko, Alexander; Javed, Hashim; Al-Hinai, Khalid; Zachariah, Matthew; Bulusu, Srinivas; Rao, Thirapathur V.

In: Neurosciences, Vol. 7, No. 2, 04.2002, p. 92-98.

Research output: Contribution to journalArticle

Koul, R, Chacko, A, Javed, H, Al-Hinai, K, Zachariah, M, Bulusu, S & Rao, TV 2002, 'A profile of childhood neuropathies at a University Hospital in Oman', Neurosciences, vol. 7, no. 2, pp. 92-98.
Koul R, Chacko A, Javed H, Al-Hinai K, Zachariah M, Bulusu S et al. A profile of childhood neuropathies at a University Hospital in Oman. Neurosciences. 2002 Apr;7(2):92-98.
Koul, Roshan ; Chacko, Alexander ; Javed, Hashim ; Al-Hinai, Khalid ; Zachariah, Matthew ; Bulusu, Srinivas ; Rao, Thirapathur V. / A profile of childhood neuropathies at a University Hospital in Oman. In: Neurosciences. 2002 ; Vol. 7, No. 2. pp. 92-98.
@article{4f9ecfb9026948aa8674fbb242cf9970,
title = "A profile of childhood neuropathies at a University Hospital in Oman",
abstract = "Objective: To analyze all cases of childhood neuropathies (under 14 years of age) and report on their profile, pattern, clinical features and management. Methods: Children with acute flaccid paralysis, longstanding weakness of extremities, neuroregression and children receiving anti cancer drugs with symptoms suggestive of neuropathy were evaluated for evidence of peripheral neuropathy. The evaluation of children with acute flaccid paralysis was a prospective study from January 1992 through to December 2000. The rest of the patients were studied retrospectively from the hospital medical records, pediatric neurology outpatient clinic and the neurophysiology laboratory, Sultan Qaboos University Hospital, Al-Khod, Oman. Results: Eighty-two (39 Male: 43 Female) children were found to have peripheral neuropathy. Acute Guillain-Barre syndrome was the most common with 37 children (45.1{\%}), followed by genetic neuropathies [hereditary motor and sensory neuropathy with 17 (20.7{\%}), hereditary sensory and autonomic neuropathy with 2 (2.4{\%}), hereditary spastic paraplegia associated neuropathy with 9 (11{\%}) and metachromatic leucodystrophy with 9 (11{\%})]. Chronic inflammatory demyelinating neuropathy was seen in 5 (6.1{\%}) and vincristine induced neuropathy in 3 (3.5{\%}) children. Conclusion: Acute Guillain-Barre syndrome is the most common neuropathy amongst the acquired neuropathies. The treatable neuropathies constituted 54.7{\%} (45 children) and the preventable genetic neuropathies accounted for the remaining 45.3{\%} (37 children).",
keywords = "Childhood neuropathies, Chronic inflammatory demyelinating neuropathy, Guillain-Barre syndrome, Hereditary neuropathies, Metachromatic leucodystrophy, Prognosis, Toxic neuropathy",
author = "Roshan Koul and Alexander Chacko and Hashim Javed and Khalid Al-Hinai and Matthew Zachariah and Srinivas Bulusu and Rao, {Thirapathur V.}",
year = "2002",
month = "4",
language = "English",
volume = "7",
pages = "92--98",
journal = "Neurosciences",
issn = "1319-6138",
publisher = "Saudi Arabian Armed Forces Hospital",
number = "2",

}

TY - JOUR

T1 - A profile of childhood neuropathies at a University Hospital in Oman

AU - Koul, Roshan

AU - Chacko, Alexander

AU - Javed, Hashim

AU - Al-Hinai, Khalid

AU - Zachariah, Matthew

AU - Bulusu, Srinivas

AU - Rao, Thirapathur V.

PY - 2002/4

Y1 - 2002/4

N2 - Objective: To analyze all cases of childhood neuropathies (under 14 years of age) and report on their profile, pattern, clinical features and management. Methods: Children with acute flaccid paralysis, longstanding weakness of extremities, neuroregression and children receiving anti cancer drugs with symptoms suggestive of neuropathy were evaluated for evidence of peripheral neuropathy. The evaluation of children with acute flaccid paralysis was a prospective study from January 1992 through to December 2000. The rest of the patients were studied retrospectively from the hospital medical records, pediatric neurology outpatient clinic and the neurophysiology laboratory, Sultan Qaboos University Hospital, Al-Khod, Oman. Results: Eighty-two (39 Male: 43 Female) children were found to have peripheral neuropathy. Acute Guillain-Barre syndrome was the most common with 37 children (45.1%), followed by genetic neuropathies [hereditary motor and sensory neuropathy with 17 (20.7%), hereditary sensory and autonomic neuropathy with 2 (2.4%), hereditary spastic paraplegia associated neuropathy with 9 (11%) and metachromatic leucodystrophy with 9 (11%)]. Chronic inflammatory demyelinating neuropathy was seen in 5 (6.1%) and vincristine induced neuropathy in 3 (3.5%) children. Conclusion: Acute Guillain-Barre syndrome is the most common neuropathy amongst the acquired neuropathies. The treatable neuropathies constituted 54.7% (45 children) and the preventable genetic neuropathies accounted for the remaining 45.3% (37 children).

AB - Objective: To analyze all cases of childhood neuropathies (under 14 years of age) and report on their profile, pattern, clinical features and management. Methods: Children with acute flaccid paralysis, longstanding weakness of extremities, neuroregression and children receiving anti cancer drugs with symptoms suggestive of neuropathy were evaluated for evidence of peripheral neuropathy. The evaluation of children with acute flaccid paralysis was a prospective study from January 1992 through to December 2000. The rest of the patients were studied retrospectively from the hospital medical records, pediatric neurology outpatient clinic and the neurophysiology laboratory, Sultan Qaboos University Hospital, Al-Khod, Oman. Results: Eighty-two (39 Male: 43 Female) children were found to have peripheral neuropathy. Acute Guillain-Barre syndrome was the most common with 37 children (45.1%), followed by genetic neuropathies [hereditary motor and sensory neuropathy with 17 (20.7%), hereditary sensory and autonomic neuropathy with 2 (2.4%), hereditary spastic paraplegia associated neuropathy with 9 (11%) and metachromatic leucodystrophy with 9 (11%)]. Chronic inflammatory demyelinating neuropathy was seen in 5 (6.1%) and vincristine induced neuropathy in 3 (3.5%) children. Conclusion: Acute Guillain-Barre syndrome is the most common neuropathy amongst the acquired neuropathies. The treatable neuropathies constituted 54.7% (45 children) and the preventable genetic neuropathies accounted for the remaining 45.3% (37 children).

KW - Childhood neuropathies

KW - Chronic inflammatory demyelinating neuropathy

KW - Guillain-Barre syndrome

KW - Hereditary neuropathies

KW - Metachromatic leucodystrophy

KW - Prognosis

KW - Toxic neuropathy

UR - http://www.scopus.com/inward/record.url?scp=0036556952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036556952&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 92

EP - 98

JO - Neurosciences

JF - Neurosciences

SN - 1319-6138

IS - 2

ER -