A family study in Oman

Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases

M. O. Hassan, S. Albarwani, S. Al Yahyaee, S. Al Haddabi, S. Rizwi, A. Jaffer, J. Al-Lawati, G. Cai, Anthony G. Comuzzie, R. A. Bayoumi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-as-certained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstand ing statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalCommunity Genetics
Volume8
Issue number1
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Oman
Pedigree
Inborn Genetic Diseases
Population Genetics
Dyslipidemias
Diabetes Mellitus
Software
Obesity
Hypertension
Phenotype
Population

Keywords

  • Complex diseases
  • Oman
  • Pedigrees

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

A family study in Oman : Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases. / Hassan, M. O.; Albarwani, S.; Al Yahyaee, S.; Al Haddabi, S.; Rizwi, S.; Jaffer, A.; Al-Lawati, J.; Cai, G.; Comuzzie, Anthony G.; Bayoumi, R. A.

In: Community Genetics, Vol. 8, No. 1, 03.2005, p. 56-60.

Research output: Contribution to journalArticle

Hassan, MO, Albarwani, S, Al Yahyaee, S, Al Haddabi, S, Rizwi, S, Jaffer, A, Al-Lawati, J, Cai, G, Comuzzie, AG & Bayoumi, RA 2005, 'A family study in Oman: Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases', Community Genetics, vol. 8, no. 1, pp. 56-60. https://doi.org/10.1159/000083341
Hassan, M. O. ; Albarwani, S. ; Al Yahyaee, S. ; Al Haddabi, S. ; Rizwi, S. ; Jaffer, A. ; Al-Lawati, J. ; Cai, G. ; Comuzzie, Anthony G. ; Bayoumi, R. A. / A family study in Oman : Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases. In: Community Genetics. 2005 ; Vol. 8, No. 1. pp. 56-60.
@article{e949c02c28214e658fe73c1de69676ec,
title = "A family study in Oman: Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases",
abstract = "Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-as-certained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstand ing statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.",
keywords = "Complex diseases, Oman, Pedigrees",
author = "Hassan, {M. O.} and S. Albarwani and {Al Yahyaee}, S. and {Al Haddabi}, S. and S. Rizwi and A. Jaffer and J. Al-Lawati and G. Cai and Comuzzie, {Anthony G.} and Bayoumi, {R. A.}",
year = "2005",
month = "3",
doi = "10.1159/000083341",
language = "English",
volume = "8",
pages = "56--60",
journal = "Public Health Genomics",
issn = "1662-4246",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - A family study in Oman

T2 - Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases

AU - Hassan, M. O.

AU - Albarwani, S.

AU - Al Yahyaee, S.

AU - Al Haddabi, S.

AU - Rizwi, S.

AU - Jaffer, A.

AU - Al-Lawati, J.

AU - Cai, G.

AU - Comuzzie, Anthony G.

AU - Bayoumi, R. A.

PY - 2005/3

Y1 - 2005/3

N2 - Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-as-certained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstand ing statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.

AB - Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-as-certained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstand ing statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.

KW - Complex diseases

KW - Oman

KW - Pedigrees

UR - http://www.scopus.com/inward/record.url?scp=20244380617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244380617&partnerID=8YFLogxK

U2 - 10.1159/000083341

DO - 10.1159/000083341

M3 - Article

VL - 8

SP - 56

EP - 60

JO - Public Health Genomics

JF - Public Health Genomics

SN - 1662-4246

IS - 1

ER -