Use of apathogenic vaccinia virus MVA expressing EHV-1 gC as basis of a combined recombinant MVA/DNA vaccination scheme

Hartwig P. Huemer*, Birgit Strobl, Norbert Nowotny

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

14 اقتباسات (Scopus)

ملخص

The nonreplicating chicken adapted vaccinia virus strain MVA was used in a combined vaccine scheme. Using the equine herpesvirus type 1 (EHV-1) encoded complement-receptor glycoprotein C as antigen, only poor antibody response was induced by exclusive vaccination with DNA plasmids. The administration of recombinant MVA followed by plasmid immunization elicited both humoral and cellular immune responses in hamster comparable to EHV-1 full virus vaccines. Our results indicate that recombinant constructs based on MVA represent a safe and efficient way to overcome problems of poor immunogenicity of certain antigens upon intramuscular DNA vaccination, thus replacing sophisticated adjuvants or application methods, which are not readily applicable in routine practice.

اللغة الأصليةEnglish
الصفحات (من إلى)1320-1326
عدد الصفحات7
دوريةVaccine
مستوى الصوت18
رقم الإصدار14
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 4 2000
منشور خارجيًانعم

ASJC Scopus subject areas

  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.2400???
  • ???subjectarea.asjc.3400???
  • ???subjectarea.asjc.2700.2739???
  • ???subjectarea.asjc.2700.2725???

بصمة

أدرس بدقة موضوعات البحث “Use of apathogenic vaccinia virus MVA expressing EHV-1 gC as basis of a combined recombinant MVA/DNA vaccination scheme'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا