Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

نتاج البحث: المساهمة في مجلةمراجعة النظراء

9 اقتباسات (Scopus)

ملخص

The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

اللغة الأصليةEnglish
الصفحات (من إلى)208-214
عدد الصفحات7
دوريةFrontiers in Bioscience - Elite
مستوى الصوت7
حالة النشرPublished - 2015

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