Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit; Sukalp Muzumdar; Ishita Gupta; Somya Shanmuganathan; Yahya Tamimi

doi:10.2741/E728

Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit^*, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Original language	English
Pages (from-to)	239-247
Number of pages	9
Journal	Frontiers in Bioscience - Elite
Volume	7E
Issue number	2
DOIs	https://doi.org/10.2741/E728
Publication status	Published - Jan 15 2015

Keywords

CAMKs
Inhibitors
Pim-1 kinase
Prostate cancer
Review

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.2741/E728

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title = "Understanding the functional discrepancy of Pim-1 in cancer",

abstract = "The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.",

keywords = "CAMKs, Inhibitors, Pim-1 kinase, Prostate cancer, Review",

author = "Allal Ouhtit and Sukalp Muzumdar and Ishita Gupta and Somya Shanmuganathan and Yahya Tamimi",

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AU - Ouhtit, Allal

AU - Muzumdar, Sukalp

AU - Gupta, Ishita

AU - Shanmuganathan, Somya

AU - Tamimi, Yahya

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

AB - The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

KW - CAMKs

KW - Inhibitors

KW - Pim-1 kinase

KW - Prostate cancer

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=84919372532&partnerID=8YFLogxK

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DO - 10.2741/E728

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AN - SCOPUS:84919372532

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VL - 7E

SP - 239

EP - 247

JO - Frontiers in Bioscience - Elite

JF - Frontiers in Bioscience - Elite

IS - 2

ER -

Understanding the functional discrepancy of Pim-1 in cancer

Abstract

Keywords

ASJC Scopus subject areas

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