Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalFrontiers in Bioscience - Elite
Volume7E
Issue number2
DOIs
Publication statusPublished - Jan 15 2015

Keywords

  • CAMKs
  • Inhibitors
  • Pim-1 kinase
  • Prostate cancer
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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