TY - JOUR
T1 - Treatment of malabsorption vitamin D deficiency myopathy with intramuscular vitamin D
AU - Alyaarubi, Saif
AU - Rodd, Celia
PY - 2005/7
Y1 - 2005/7
N2 - A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait. He was known to have cholestatic liver disease. Investigations revealed markedly low serum total calcium, elevated alkaline phosphatase, very low serum 25-hydroxyvitamin D, and radiographs consistent with active rickets despite the ongoing administration of a water-soluble preparation of vitamin D. Only i.v. calcitriol acutely corrected the hypocalcemia, despite trying several oral preparations, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets. Intramuscular calciferol quickly corrected his muscle weakness and X-ray findings. Myopathy secondary to vitamin D deficiency is an uncommon diagnosis in children. Intermittent calciferol is an inexpensive and practical treatment for vitamin D deficiency, especially if associated with malabsorption.
AB - A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait. He was known to have cholestatic liver disease. Investigations revealed markedly low serum total calcium, elevated alkaline phosphatase, very low serum 25-hydroxyvitamin D, and radiographs consistent with active rickets despite the ongoing administration of a water-soluble preparation of vitamin D. Only i.v. calcitriol acutely corrected the hypocalcemia, despite trying several oral preparations, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets. Intramuscular calciferol quickly corrected his muscle weakness and X-ray findings. Myopathy secondary to vitamin D deficiency is an uncommon diagnosis in children. Intermittent calciferol is an inexpensive and practical treatment for vitamin D deficiency, especially if associated with malabsorption.
KW - Intramuscular calciferol
KW - Malabsorption
KW - Progressive familial intrahepatic cholestasis
KW - Vitamin D deficiency
UR - http://www.scopus.com/inward/record.url?scp=23644440122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23644440122&partnerID=8YFLogxK
U2 - 10.1515/JPEM.2005.18.7.719
DO - 10.1515/JPEM.2005.18.7.719
M3 - Article
C2 - 16128249
AN - SCOPUS:23644440122
SN - 0334-018X
VL - 18
SP - 719
EP - 722
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 7
ER -