THE EFFECT OF SOME α2‐ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON GASTROINTESTINAL TRANSIT IN MICE: INFLUENCE OF MORPHINE, CASTOR OIL AND GLUCOSE

B. H. Ali*, A. A. Bashir

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

19 اقتباسات (Scopus)

ملخص

1. The effects of graded doses of the α2‐adrenoceptor agonists clonidine, tizanidine and BHT‐920, and the α2‐adrenoceptor antagonists yohimbine and idazoxan, on gastrointestinal transit were investigated in mice using the charcoal meal test. 2. The agonists produced significant and dose‐dependent decreases in gastrointestinal transit, and the antagonists produced the opposite effect. In affecting the gastrointestinal transit, clonidine (1 mg/kg) was as effective as tizanidine (12 mg/kg) and BHT‐920 (40 mg/kg), while yohimbine (2 mg/kg) was as effective as idazoxan (1 mg/kg). 3. Morphine (2, 4 and 8 mg/kg) significantly inhibited gastrointestinal transit. This effect was significantly reversed by the co‐administration of yohimbine (2 mg/kg) and idazoxan (1 mg/kg). 4. The acute administration of glucose (5.04 g/kg, i.p.) potentiated the inhibition of gastrointestinal transit produced by clonidine (1 mg/kg) and BHT‐920 (40 mg/kg). Glucose treatment, however, had no significant effect on the increase in gastrointestinal transit induced by yohimbine (2 mg/kg) or idazoxan (1 mg/kg). 5. Castor oil (0.25 mL/mouse, orally) induced diarrhoea in saline‐treated animals within about 45 min. Clonidine (1 mg/kg), tizanidine (12 mg/kg) and BHT‐920 (40 mg/kg) delayed the occurrence of diarrhoea to 2.1, 1.2 and 1.4 h, respectively.

اللغة الأصليةEnglish
الصفحات (من إلى)1-6
عدد الصفحات6
دوريةClinical and Experimental Pharmacology and Physiology
مستوى الصوت20
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يناير 1993

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “THE EFFECT OF SOME α2‐ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON GASTROINTESTINAL TRANSIT IN MICE: INFLUENCE OF MORPHINE, CASTOR OIL AND GLUCOSE'. فهما يشكلان معًا بصمة فريدة.

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