ملخص
A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using1H NMR,13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.
اللغة الأصلية | English |
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رقم المقال | 4240 |
دورية | Molecules |
مستوى الصوت | 26 |
رقم الإصدار | 14 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - يوليو 2 2021 |
ASJC Scopus subject areas
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