Potential protective effect of etanercept and aminoguanidine in methotrexate-induced hepatotoxicity and nephrotoxicity in rats

Agricultural and Biological Sciences

• Hepatotoxicity 100%
• Nephrotoxicity 100%
• Tumor Necrosis Factors 83%
• Inducible Nitric Oxide Synthase 83%
• Protective Effect 66%
• Caspase 3 50%
• Oxidative Stress 33%
• Antioxidant 16%
• Superoxide Dismutase 16%
• Aspartate Transaminase 16%
• Glutathione 16%
• Alanine 16%
• Urea 16%
• Creatinine 16%
• Catalase 16%
• Immunosuppressive Agent 16%

Medicine and Dentistry

• Aminoguanidine 60%
• Etanercept 60%
• TNF Inhibitor 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Etanercept 60%
• Aminoguanidine 60%
• Tumor Necrosis Factor Inhibitor 10%