Phenylbutazone pharmacokinetics and bioavailability in the Dromedary camel (camelus dromedarius)

A. Kadir*, B. H. Ali, G. A.L. Hadrami, A. K. Bashir, M. F. Landoni, P. Lees

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

17 اقتباسات (Scopus)

ملخص

Phenylbutazone was administered intravenously and intramuscularly at a dosage rate of 4.4 mg/kg to a group of 6 female camels in a two-period crossover study. After intravenous (i.v.) administration, disposition was characterised by a two-compartment open model, with a low volume of distribution (0.174 l.kg-1), and distribution and elimination half-lives of 0.43 and 12.51 h, respectively. After intramuscular (i.m.) dosing absorption was relatively rapid with absorption half-time and time of maximal concentration values of 1.14 and 3.95 h, respectively. Plateau concentrations of phenylbutazone in plasma were obtained between 2 and 12 h and mean bioavailability was 97%, although this was subject to wide inter-animal differences. Plasma concentrations of the phenylbutazone metabolite, oxyphenbutazone, were low after iv dosing and generally undetectable after im administration, indicating that it is unlikely to contribute significantly to the pharmacological effects produced by phenylbutazone administration. An indication was obtained that phenylbutazone inhibited the ex vivo synthesis of serum thromboxane B2 (TxB2) for 24 h after i.v. dosing, but this finding requires confirmation.

اللغة الأصليةEnglish
الصفحات (من إلى)54-60
عدد الصفحات7
دوريةJournal of Veterinary Pharmacology and Therapeutics
مستوى الصوت20
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 1997

ASJC Scopus subject areas

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بصمة

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