New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)

Majekodunmi O. Fatope; Lu Zeng; Joseph E. Ohayagha; Jerry L. McLaughlin

doi:10.1016/0968-0896(96)00157-5

New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)

Majekodunmi O. Fatope, Lu Zeng, Joseph E. Ohayagha, Jerry L. McLaughlin^*

^*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

12 اقتباسات (Scopus)

ملخص

The poisonous latex of Euphorbia poisonii gave bioactive 3,12-diacetyl-8-nicotinyl-7-phenylacetyl 19-acetoxyingol (1) together with its less active congeners, 3,12-diacetyl-7-phenylacetyl 19-acetoxyingol (2) and 3-acetyl-7-phenylacetyl 19-acetoxyingol (3). The chemical structures of 1-3 were determined by spectroscopic methods including HRMS, DEPT, HETCOR, COSY, NOESY, HMQC and HMBC. The absolute configurations of the hydroxylated carbons in 2 and 3 were provisionally suggested by the Mosher ester method. Bioactivity-guided isolation, structure determination and cytotoxic activity of the new ingols are described.

اللغة الأصلية	English
الصفحات (من إلى)	1679-1683
عدد الصفحات	5
دورية	Bioorganic and Medicinal Chemistry
مستوى الصوت	4
رقم الإصدار	10
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/0968-0896(96)00157-5
حالة النشر	Published - أكتوبر 1996
منشور خارجيًا	نعم

ASJC Scopus subject areas

???subjectarea.asjc.1300.1303???
???subjectarea.asjc.1300.1313???
???subjectarea.asjc.1300.1312???
???subjectarea.asjc.3000.3003???
???subjectarea.asjc.3000.3002???
???subjectarea.asjc.1300.1308???
???subjectarea.asjc.1600.1605???

الوصول إلى المستند

10.1016/0968-0896(96)00157-5

الملفات والروابط الأخرى

قم بذكر هذا

@article{ab0cf4457dba47f893e1ae767b4d0827,

title = "New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)",

abstract = "The poisonous latex of Euphorbia poisonii gave bioactive 3,12-diacetyl-8-nicotinyl-7-phenylacetyl 19-acetoxyingol (1) together with its less active congeners, 3,12-diacetyl-7-phenylacetyl 19-acetoxyingol (2) and 3-acetyl-7-phenylacetyl 19-acetoxyingol (3). The chemical structures of 1-3 were determined by spectroscopic methods including HRMS, DEPT, HETCOR, COSY, NOESY, HMQC and HMBC. The absolute configurations of the hydroxylated carbons in 2 and 3 were provisionally suggested by the Mosher ester method. Bioactivity-guided isolation, structure determination and cytotoxic activity of the new ingols are described.",

keywords = "Cytotoxic activity, Euphorbia poisonii, Euphorbiaceae, Ingol diterpenes",

author = "Fatope, {Majekodunmi O.} and Lu Zeng and Ohayagha, {Joseph E.} and McLaughlin, {Jerry L.}",

year = "1996",

month = oct,

doi = "10.1016/0968-0896(96)00157-5",

language = "English",

volume = "4",

pages = "1679--1683",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "10",

}

TY - JOUR

T1 - New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)

AU - Fatope, Majekodunmi O.

AU - Zeng, Lu

AU - Ohayagha, Joseph E.

AU - McLaughlin, Jerry L.

PY - 1996/10

Y1 - 1996/10

N2 - The poisonous latex of Euphorbia poisonii gave bioactive 3,12-diacetyl-8-nicotinyl-7-phenylacetyl 19-acetoxyingol (1) together with its less active congeners, 3,12-diacetyl-7-phenylacetyl 19-acetoxyingol (2) and 3-acetyl-7-phenylacetyl 19-acetoxyingol (3). The chemical structures of 1-3 were determined by spectroscopic methods including HRMS, DEPT, HETCOR, COSY, NOESY, HMQC and HMBC. The absolute configurations of the hydroxylated carbons in 2 and 3 were provisionally suggested by the Mosher ester method. Bioactivity-guided isolation, structure determination and cytotoxic activity of the new ingols are described.

AB - The poisonous latex of Euphorbia poisonii gave bioactive 3,12-diacetyl-8-nicotinyl-7-phenylacetyl 19-acetoxyingol (1) together with its less active congeners, 3,12-diacetyl-7-phenylacetyl 19-acetoxyingol (2) and 3-acetyl-7-phenylacetyl 19-acetoxyingol (3). The chemical structures of 1-3 were determined by spectroscopic methods including HRMS, DEPT, HETCOR, COSY, NOESY, HMQC and HMBC. The absolute configurations of the hydroxylated carbons in 2 and 3 were provisionally suggested by the Mosher ester method. Bioactivity-guided isolation, structure determination and cytotoxic activity of the new ingols are described.

KW - Cytotoxic activity

KW - Euphorbia poisonii

KW - Euphorbiaceae

KW - Ingol diterpenes

UR - http://www.scopus.com/inward/record.url?scp=0030271682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030271682&partnerID=8YFLogxK

U2 - 10.1016/0968-0896(96)00157-5

DO - 10.1016/0968-0896(96)00157-5

M3 - Article

C2 - 8931937

AN - SCOPUS:0030271682

SN - 0968-0896

VL - 4

SP - 1679

EP - 1683

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 10

ER -

New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)

ملخص

ASJC Scopus subject areas

الوصول إلى المستند

الملفات والروابط الأخرى

بصمة

قم بذكر هذا