Invasive pleomorphic lobular carcinoma of the breast: Pathologic, clinical, and therapeutic considerations

Khalid Al-Baimani, Amy Bazzarelli, Mark Clemons, Susan J. Robertson, Christina Addison, Angel Arnaout*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

22 اقتباسات (Scopus)

ملخص

Pleomorphic lobular carcinoma is an uncommon form of breast cancer and a subtype of invasive lobular carcinoma. It has unique histopathologic features that translate to a more aggressive phenotype with an associated poor prognosis. Unlike classical invasive lobular carcinoma, it can lose estrogen and progesterone receptor expression and demonstrate HER-2/neu amplification. It remains to be determined, however, whether the pleomorphic histology independently predicts a worse outcome or whether other known associated negative prognostic factors such as larger tumor size, increased metastatic disease, and associated worse molecular subtypes commonly present in pleomorphic carcinoma account for the poor prognosis. Here we present an updated review of the unique pathologic and clinical features of pleomorphic lobular carcinoma needed to guide management for women with this subtype of cancer.

اللغة الأصليةEnglish
الصفحات (من إلى)421-425
عدد الصفحات5
دوريةClinical Breast Cancer
مستوى الصوت15
رقم الإصدار6
المعرِّفات الرقمية للأشياء
حالة النشرPublished - ديسمبر 2015

ASJC Scopus subject areas

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