Drug resistance-virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission

Hayder A. Giha*, Mustafa I. Elbashir, Ishraga E. A-Elbasit, Thoraya M.E. A-Elgadir, Gehad E. ElGhazali, Margaret J. Mackinnon, Hamza A. Babiker

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

30 اقتباسات (Scopus)

ملخص

The pathogenesis of severe Plasmodium falciparum malaria is still obscure, but is believed to be multi-factorial, and among the important factors are intrinsic parasite-properties. Here we investigated the association between clinical manifestation of P. falciparum malaria (an indicator of virulence) and two parasite properties - drug resistance and gametocyte production. Among 996 P. falciparum infections detected in the out-patient clinic of Gedarif Hospital in eastern Sudan, there was no significant association between the incidence of severe versus mild disease and the presence of resistant alleles at the chloroquine-resistance transporter locus (pfcrt-T76) and the multi-drug-resistance locus (pfmdr1-Y86). However, among severe cases, there was a significantly lower prevalence of parasites carrying resistant alleles among patients that died versus survived. There was a trend towards a higher gametocyte rate among severe malaria patients compared with uncomplicated malaria cases. These results are discussed in relation to the fitness of drug resistant parasites.

اللغة الأصليةEnglish
الصفحات (من إلى)181-187
عدد الصفحات7
دوريةActa Tropica
مستوى الصوت97
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 2006
منشور خارجيًانعم

ASJC Scopus subject areas

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  • ???subjectarea.asjc.3400.3401???
  • ???subjectarea.asjc.1100.1109???
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