Brucella Periprosthetic Joint Infection Involving Bilateral Knees with Negative Synovial Fluid Alpha-Defensin

Abdullah Balkhair, Sultan Al Maskari, Shadin Ibrahim, Ibrahim Al Busaidi, Mohammed Al Amin, Hashim Ba Taher

نتاج البحث: المساهمة في مجلةمراجعة النظراء

ملخص

Periprosthetic joint infection (PJI) due to Brucella is uncommon despite relatively high endemicity of human brucellosis and its osteoarticular predilection. We report a case of a 57-year-old woman with bacteraemic brucellosis complicated by Brucella periprosthetic infection of both knee joints occurring a decade after bilateral knee arthroplasty and associated with a negative synovial fluid alpha-defensin test. The patient was successfully treated with anti-Brucella therapy alone and without surgical revision, resulting in clinical and microbiological cure. We propose that Brucella should be considered as a possible cause of prosthetic joint infection in the appropriate clinical and epidemiological settings. A negative synovial fluid alpha-defensin (Synovasure AD test) should not be used as a rule-out test for Brucella PJI. Brucella PJI without radiological loosening may be treated conservatively and solely with antimicrobial therapy.

اللغة الأصليةEnglish
الصفحات (من إلى)9423946
دوريةCase reports in infectious diseases
مستوى الصوت2019
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2019

بصمة

أدرس بدقة موضوعات البحث “Brucella Periprosthetic Joint Infection Involving Bilateral Knees with Negative Synovial Fluid Alpha-Defensin'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا