TY - JOUR
T1 - Biophysical interaction of resveratrol with sirtuin pathway
T2 - Significance in Alzheimer’s disease
AU - Mohan, Sathya
AU - Gobinath, Thilagar
AU - Salomy, Arul
AU - Nisha, Meher
AU - Kandasamy, Mahesh
AU - Essa, Musthafa Mohamed
AU - Jayachandran, Kesavan Swaminathan
AU - Anusuyadevi, Muthuswamy
N1 - Publisher Copyright:
© 2018 Frontiers in Bioscience. All Rights Reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Alzheimer disease (AD) is a widespread neurodegenerativeconditionthatleadstoprogressive cognitive dysfunction in elderly population. Despite several attempts aimed at molecular determinants of AD, effective disease modifying treatment options are highly limited. Recently, use of natural supplements has gained considerable attention in AD research due to their cost effective and long lasting health beneficial properties. Resveratrol (RSV) is a naturally occurring polyphenolic compound found majorly in grapes. RSV has been shown to exert a plethora of medical benefits due to its anti-oxidant, anti–aging, anti-inflammatory, anti–malignant and neuroprotective properties. In particular, RSV has been shown to increase memory performance. The neuroprotective effect of RSV has strongly been linked to the depolymerization of amyloid β fibrils. However, the molecular targets of RSV remain the subject of investigation. This review was aimed to comprehend the existing knowledge on the neuroprotective effects of RSV and recent progress made on understanding the role RVS in the regulation of neural plasticity through a molecular target Sirtuin 1, a potential homeostatic regulator in AD.
AB - Alzheimer disease (AD) is a widespread neurodegenerativeconditionthatleadstoprogressive cognitive dysfunction in elderly population. Despite several attempts aimed at molecular determinants of AD, effective disease modifying treatment options are highly limited. Recently, use of natural supplements has gained considerable attention in AD research due to their cost effective and long lasting health beneficial properties. Resveratrol (RSV) is a naturally occurring polyphenolic compound found majorly in grapes. RSV has been shown to exert a plethora of medical benefits due to its anti-oxidant, anti–aging, anti-inflammatory, anti–malignant and neuroprotective properties. In particular, RSV has been shown to increase memory performance. The neuroprotective effect of RSV has strongly been linked to the depolymerization of amyloid β fibrils. However, the molecular targets of RSV remain the subject of investigation. This review was aimed to comprehend the existing knowledge on the neuroprotective effects of RSV and recent progress made on understanding the role RVS in the regulation of neural plasticity through a molecular target Sirtuin 1, a potential homeostatic regulator in AD.
KW - Alzheimer’s disease
KW - Neuroprotection
KW - Resveratrol
KW - Review
KW - SIRT1
UR - http://www.scopus.com/inward/record.url?scp=85046841659&partnerID=8YFLogxK
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U2 - 10.2741/4650
DO - 10.2741/4650
M3 - Article
C2 - 29293440
AN - SCOPUS:85046841659
SN - 2768-6701
VL - 23
SP - 1380
EP - 1390
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
IS - 7
ER -