TY - JOUR
T1 - Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica
AU - Ragab, Ehab A.
AU - Hosny, Mohammed
AU - Kadry, Hazem A.
AU - Ammar, Hassan A.
PY - 2010
Y1 - 2010
N2 - Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.
AB - Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.
KW - Acylated triterpenoidal saponins
KW - Cytokinins
KW - Gleditsia aquatica
KW - NMR
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M3 - Article
AN - SCOPUS:77954832139
SN - 2141-2502
VL - 2
SP - 24
EP - 33
JO - Journal of Pharmacognosy and Phytotherapy
JF - Journal of Pharmacognosy and Phytotherapy
IS - 3
ER -