West nile and usutu virus infections and challenges to blood safety in the European Union

Dragoslav Domanović; Celine M. Gossner; Ryanne Lieshout-Krikke; Wolfgang Mayr; Klara Baroti-Toth; Alina Mirella Dobrota; Maria Antonia Escoval; Olaf Henseler; Christof Jungbauer; Giancarlo Liumbruno; Salvador Oyonarte; Constantina Politis; Imad Sandid; Miljana Stojić Vidović; Johanna J. Young; Inês Ushiro-Lumb; Norbert Nowotny

doi:10.3201/eid2506.181755

West nile and usutu virus infections and challenges to blood safety in the European Union

Dragoslav Domanović^*, Celine M. Gossner, Ryanne Lieshout-Krikke, Wolfgang Mayr, Klara Baroti-Toth, Alina Mirella Dobrota, Maria Antonia Escoval, Olaf Henseler, Christof Jungbauer, Giancarlo Liumbruno, Salvador Oyonarte, Constantina Politis, Imad Sandid, Miljana Stojić Vidović, Johanna J. Young, Inês Ushiro-Lumb, Norbert Nowotny

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion- transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries and assessed the safety of the blood supply by compiling data on WNV positivity among blood donors and on reported TT-WNV cases. The paucity of reported TTWNV infections and the screening results suggest that blood safety interventions are effective. However, limited circulation of WNV in the EU and presumed underrecognition or underreporting of TT-WNV cases contribute to the present situation. Because of cross-reactivity between genetically related flaviviruses in the automated nucleic acid test systems, USUV-positive blood donations are found during routine WNV screening. The clinical relevance of USUV infection in humans and the risk of USUV to blood safety are unknown.

Original language	English
Pages (from-to)	1050-1057
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	25
Issue number	6
DOIs	https://doi.org/10.3201/eid2506.181755
Publication status	Published - Jun 2019
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid2506.181755

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Domanović, D., Gossner, C. M., Lieshout-Krikke, R., Mayr, W., Baroti-Toth, K., Dobrota, A. M., Escoval, M. A., Henseler, O., Jungbauer, C., Liumbruno, G., Oyonarte, S., Politis, C., Sandid, I., Vidović, M. S., Young, J. J., Ushiro-Lumb, I., & Nowotny, N. (2019). West nile and usutu virus infections and challenges to blood safety in the European Union. Emerging Infectious Diseases, 25(6), 1050-1057. https://doi.org/10.3201/eid2506.181755

Domanović, D, Gossner, CM, Lieshout-Krikke, R, Mayr, W, Baroti-Toth, K, Dobrota, AM, Escoval, MA, Henseler, O, Jungbauer, C, Liumbruno, G, Oyonarte, S, Politis, C, Sandid, I, Vidović, MS, Young, JJ, Ushiro-Lumb, I & Nowotny, N 2019, 'West nile and usutu virus infections and challenges to blood safety in the European Union', Emerging Infectious Diseases, vol. 25, no. 6, pp. 1050-1057. https://doi.org/10.3201/eid2506.181755

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abstract = "West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion- transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries and assessed the safety of the blood supply by compiling data on WNV positivity among blood donors and on reported TT-WNV cases. The paucity of reported TTWNV infections and the screening results suggest that blood safety interventions are effective. However, limited circulation of WNV in the EU and presumed underrecognition or underreporting of TT-WNV cases contribute to the present situation. Because of cross-reactivity between genetically related flaviviruses in the automated nucleic acid test systems, USUV-positive blood donations are found during routine WNV screening. The clinical relevance of USUV infection in humans and the risk of USUV to blood safety are unknown.",

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AU - Baroti-Toth, Klara

AU - Dobrota, Alina Mirella

AU - Escoval, Maria Antonia

AU - Henseler, Olaf

AU - Jungbauer, Christof

AU - Liumbruno, Giancarlo

AU - Oyonarte, Salvador

AU - Politis, Constantina

AU - Sandid, Imad

AU - Vidović, Miljana Stojić

AU - Young, Johanna J.

AU - Ushiro-Lumb, Inês

AU - Nowotny, Norbert

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West nile and usutu virus infections and challenges to blood safety in the European Union

Abstract

ASJC Scopus subject areas

UN SDGs

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