TY - JOUR
T1 - Deficiência de vitamina b12 em cabritos recém-desmamados associada à infecção clínica por eimeria arloingi
AU - Al-Habsi, Khalid
AU - Ali, Haytham
AU - Al-Kharousi, Kaadhia
AU - Elshafie, Elshafie Ibrahim
AU - Al-Busaidi, Rashid
AU - Muhiuddin, Anwar
AU - Johnson, Eugene Harper
N1 - Publisher Copyright:
© 2020, Brazilain Coll Veterinary Parasitology. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - A severe outbreak of diarrhea associated with poor growth was reported in ten newly weaned goat kids that originated from a research farm (Group A). Two of these kids underwent necropsy examination. Five goat kids of the same age maintained in the same pen showed no clinical signs (Group B). The clinical, gross pathological and histopathological features of the clinically sick animals were consistent with severe coccidiosis. Group A animals had significantly lower levels of serum vitamin B12 (<200 pg/ml) compared with group B animals (2000 pg/ml). In addition, kids belonging to group A had significantly higher Eimeria arloingi oocysts per gram (OPG) of faeces (101,400/g) compared with kids of group B (9,154/g). Microscopy and molecular tools (18S rRNA and COI genes) confirmed that the goat kids were infected with the caprine protozoan parasite E. arloingi. This study provides a definitive association between low levels of serum vitamin B12 and clinical E. arloingi infection, and also provides support to our previous studies that demonstrated how low levels of serum vitamin B12 leads to an impairment of neutrophil function and thereby potential lowered immunity to pathogens.
AB - A severe outbreak of diarrhea associated with poor growth was reported in ten newly weaned goat kids that originated from a research farm (Group A). Two of these kids underwent necropsy examination. Five goat kids of the same age maintained in the same pen showed no clinical signs (Group B). The clinical, gross pathological and histopathological features of the clinically sick animals were consistent with severe coccidiosis. Group A animals had significantly lower levels of serum vitamin B12 (<200 pg/ml) compared with group B animals (2000 pg/ml). In addition, kids belonging to group A had significantly higher Eimeria arloingi oocysts per gram (OPG) of faeces (101,400/g) compared with kids of group B (9,154/g). Microscopy and molecular tools (18S rRNA and COI genes) confirmed that the goat kids were infected with the caprine protozoan parasite E. arloingi. This study provides a definitive association between low levels of serum vitamin B12 and clinical E. arloingi infection, and also provides support to our previous studies that demonstrated how low levels of serum vitamin B12 leads to an impairment of neutrophil function and thereby potential lowered immunity to pathogens.
KW - 18S rRNA
KW - Cobalt
KW - COI
KW - Eimeria arloingi
KW - Goats
KW - Vitamin B
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U2 - 10.1590/s1984-29612020078
DO - 10.1590/s1984-29612020078
M3 - Article
C2 - 33053054
AN - SCOPUS:85092383553
VL - 29
SP - 1
EP - 9
JO - Revista Brasileira de Parasitologia Veterinaria
JF - Revista Brasileira de Parasitologia Veterinaria
SN - 0103-846X
IS - 4
M1 - e005920
ER -