Abstract
The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.
| Original language | English |
|---|---|
| Pages (from-to) | 45-48 |
| Number of pages | 4 |
| Journal | Sultan Qaboos University Medical Journal |
| Volume | 4 |
| Issue number | 1-2 |
| Publication status | Published - Apr 1 2002 |
Fingerprint
Keywords
- Haemophagocytic syndrome
- Oman
- Visceral leishmaniasis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Visceral leishmaniasis and haemophagocytic syndrome in an Omani child. / Al Sineidi, Khalfan; Wali, Yasser A.; Pathare, Anil V.; Al Lamki, Zakia.
In: Sultan Qaboos University Medical Journal, Vol. 4, No. 1-2, 01.04.2002, p. 45-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visceral leishmaniasis and haemophagocytic syndrome in an Omani child
AU - Al Sineidi, Khalfan
AU - Wali, Yasser A.
AU - Pathare, Anil V.
AU - Al Lamki, Zakia
PY - 2002/4/1
Y1 - 2002/4/1
N2 - The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.
AB - The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.
KW - Haemophagocytic syndrome
KW - Oman
KW - Visceral leishmaniasis
UR - http://www.scopus.com/inward/record.url?scp=33748252305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748252305&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33748252305
VL - 4
SP - 45
EP - 48
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
SN - 2075-051X
IS - 1-2
ER -