VIPoma crisis

Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide

Omayma ElShafie, Christopher Grant, Aisha Al-Hamdani, Rajeev Jain, Nicholas Woodhouse

Research output: Contribution to journalArticle

Abstract

We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. This was complicated by severe hypotension, hypokalaemia, hypercalcaemia, renal failure requiring dialysis, metabolic acidosis, cardiorespiratory arrest and ventilation for 12 days. His diarrhoea responded immediately to the first dose of a therapeutic trial of subcutaneous octreotide 100 mcg 8 hourly which was started on clinical grounds alone before any investigations were carried out. After one day he was extubated and his blood pressure returned to normal. When a functioning neuroendocrine tumour is suspected clinically, the use of octreotide can, as in this case, be life saving.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume11
Issue number1
Publication statusPublished - Feb 2011

Fingerprint

Vipoma
Octreotide
Diarrhea
Neuroendocrine Tumors
Hypokalemia
Hypercalcemia
Acidosis
Hypotension
Renal Insufficiency
Ventilation
Dialysis
Blood Pressure
Physicians
Therapeutics

Keywords

  • Cardiopulmonary arrest
  • Case report
  • Chromogranin A
  • Diarrhoea
  • Neuroendocrine tumour
  • Octreotide
  • Oman
  • Pancreatic tumour
  • VIPoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

VIPoma crisis : Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. / ElShafie, Omayma; Grant, Christopher; Al-Hamdani, Aisha; Jain, Rajeev; Woodhouse, Nicholas.

In: Sultan Qaboos University Medical Journal, Vol. 11, No. 1, 02.2011, p. 104-108.

Research output: Contribution to journalArticle

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