Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

Roshan Koul, Saleem Saleh Naiha Al Harousi, Sousan Alnabhani, Amna Alfutaisi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The main objective of this article was to evaluate vincristine neuropathy effect on common peroneal and tibial nerves. Methods A retrospective study was conducted in children with vincristine neuropathy between August 2006 and January 2016 at Sultan Qaboos University Hospital. Results Twenty-eight children (15 females and 13 males) were included in the study. The compound muscle action potential of common peroneal nerves was significantly reduced relative to the tibial nerves (p < 0.05)). There was no difference in latency and nerve conduction velocity between the two nerves. Conclusion Children receiving vincristine demonstrate severe peroneal neuropathy compared with tibial nerves. We conclude that squatting posture effects peroneal nerves and postulate that the peroneal nerves are affected more due to the squatting posture. This squatting posture stretches the nerves that are already affected by the toxic effect of vincristine.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalJournal of Pediatric Neurology
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • children
  • squatting
  • vincristine neuropathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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