Vascular stenosis in a child with visual pathway glioma treated with bevacizumab: a case report and review of literature

Chiara Pilotto*, Ismail Beshlawi, Adam Thomas, Richard G. Grundy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Bevacizumab (BVZ) is a vascular endothelial growth factor inhibitor that has been widely accepted since its introduction into the cancer pharmacopoeia. Anecdotal reports suggested improvements in vision in children with visual pathway glioma. Case presentation: We report a boy with visual pathway glioma whose vision had deteriorated significantly on vincristine and carboplatin, to the point that he was registered blind. Following bevacizumab therapy, there was a dramatic improvement in vision with reduction in tumour volume. However, following 20 doses of BVZ given over 19 months, he developed a significant cerebrovascular stenosis. Conclusion: The BVZ-induced cerebrovascular diseases in children are extremely rare but potentially serious. Importantly, stenosis has not been previously described in literature.

Original languageEnglish
Pages (from-to)781-785
Number of pages5
JournalChild's Nervous System
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 1 2018
Externally publishedYes

Keywords

  • Adverse effects
  • Bevacizumab
  • Cerebrovascular stenosis
  • Visual pathway glioma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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