Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease

Chinnasamy Dhanalakshmi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ameer Kalandar, Mohammed Abdul Sattar Khan, Gilles J. Guillemin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalNeurochemical Research
DOIs
Publication statusAccepted/In press - Apr 2 2016

Fingerprint

Rotenone
Oxidative stress
Parkinson Disease
Rats
Oxidative Stress
Apoptosis
Neuroprotective Agents
Food and Beverages
Beverages
Cosmetics
Aromatic compounds
Food Industry
Drug Industry
Blood-Brain Barrier
Oral Administration
vanillin
Anti-Inflammatory Agents
Antioxidants
Pharmaceutical Preparations
Industry

Keywords

  • Motor and non-motor symptoms
  • Oxidative stress, apoptosis
  • Parkinson’s disease
  • Vanillin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

Cite this

Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease. / Dhanalakshmi, Chinnasamy; Janakiraman, Udaiyappan; Manivasagam, Thamilarasan; Justin Thenmozhi, Arokiasamy; Essa, Musthafa Mohamed; Kalandar, Ameer; Khan, Mohammed Abdul Sattar; Guillemin, Gilles J.

In: Neurochemical Research, 02.04.2016, p. 1-12.

Research output: Contribution to journalArticle

Dhanalakshmi, Chinnasamy ; Janakiraman, Udaiyappan ; Manivasagam, Thamilarasan ; Justin Thenmozhi, Arokiasamy ; Essa, Musthafa Mohamed ; Kalandar, Ameer ; Khan, Mohammed Abdul Sattar ; Guillemin, Gilles J. / Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease. In: Neurochemical Research. 2016 ; pp. 1-12.
@article{b847b3859a99447ca99f83e2eafb89cf,
title = "Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease",
abstract = "Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.",
keywords = "Motor and non-motor symptoms, Oxidative stress, apoptosis, Parkinson’s disease, Vanillin",
author = "Chinnasamy Dhanalakshmi and Udaiyappan Janakiraman and Thamilarasan Manivasagam and {Justin Thenmozhi}, Arokiasamy and Essa, {Musthafa Mohamed} and Ameer Kalandar and Khan, {Mohammed Abdul Sattar} and Guillemin, {Gilles J.}",
year = "2016",
month = "4",
day = "2",
doi = "10.1007/s11064-016-1901-5",
language = "English",
pages = "1--12",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer New York",

}

TY - JOUR

T1 - Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease

AU - Dhanalakshmi, Chinnasamy

AU - Janakiraman, Udaiyappan

AU - Manivasagam, Thamilarasan

AU - Justin Thenmozhi, Arokiasamy

AU - Essa, Musthafa Mohamed

AU - Kalandar, Ameer

AU - Khan, Mohammed Abdul Sattar

AU - Guillemin, Gilles J.

PY - 2016/4/2

Y1 - 2016/4/2

N2 - Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.

AB - Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.

KW - Motor and non-motor symptoms

KW - Oxidative stress, apoptosis

KW - Parkinson’s disease

KW - Vanillin

UR - http://www.scopus.com/inward/record.url?scp=84962163532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962163532&partnerID=8YFLogxK

U2 - 10.1007/s11064-016-1901-5

DO - 10.1007/s11064-016-1901-5

M3 - Article

SP - 1

EP - 12

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

ER -