Validation of a non-invasive pulse CO-oximetry based hemoglobin estimation in normal blood donors

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Abstract

Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21%). In the multivariable model, height (p=0.015) and Hb level (p2=60%). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalTransfusion and Apheresis Science
Volume50
Issue number1
DOIs
Publication statusPublished - 2014

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Oximetry
Carbon Monoxide
Blood Donors
Hemoglobins
Linear Models
Prospective Studies
Blood Banks
Aluminum Oxide
Hematology
Tertiary Healthcare
Tertiary Care Centers
Observational Studies
Tissue Donors
Blood Pressure
Weights and Measures

Keywords

  • Blood donors
  • Hemoglobin
  • Non-invasive
  • Validation

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

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title = "Validation of a non-invasive pulse CO-oximetry based hemoglobin estimation in normal blood donors",
abstract = "Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21{\%}). In the multivariable model, height (p=0.015) and Hb level (p2=60{\%}). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.",
keywords = "Blood donors, Hemoglobin, Non-invasive, Validation",
author = "Murtadha Al-Khabori and Al-Riyami, {Arwa Z.} and Khalil Al-Farsi and Mohamed Al-Huneini and Abdulhakeem Al-Hashim and Nasser Al-Kemyani and Shahina Daar",
year = "2014",
doi = "10.1016/j.transci.2013.10.007",
language = "English",
volume = "50",
pages = "95--98",
journal = "Transfusion and Apheresis Science",
issn = "1473-0502",
publisher = "Elsevier Limited",
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TY - JOUR

T1 - Validation of a non-invasive pulse CO-oximetry based hemoglobin estimation in normal blood donors

AU - Al-Khabori, Murtadha

AU - Al-Riyami, Arwa Z.

AU - Al-Farsi, Khalil

AU - Al-Huneini, Mohamed

AU - Al-Hashim, Abdulhakeem

AU - Al-Kemyani, Nasser

AU - Daar, Shahina

PY - 2014

Y1 - 2014

N2 - Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21%). In the multivariable model, height (p=0.015) and Hb level (p2=60%). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.

AB - Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21%). In the multivariable model, height (p=0.015) and Hb level (p2=60%). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.

KW - Blood donors

KW - Hemoglobin

KW - Non-invasive

KW - Validation

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