TY - JOUR
T1 - Validation of a non-invasive pulse CO-oximetry based hemoglobin estimation in normal blood donors
AU - Al-Khabori, Murtadha
AU - Al-Riyami, Arwa Z.
AU - Al-Farsi, Khalil
AU - Al-Huneini, Mohamed
AU - Al-Hashim, Abdulhakeem
AU - Al-Kemyani, Nasser
AU - Daar, Shahina
PY - 2014/2
Y1 - 2014/2
N2 - Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21%). In the multivariable model, height (p=0.015) and Hb level (p<0.001) were statistically significant predictors. A strong correlation was found between the two CO-oximetry Hb measurements (coefficient 0.78, R2=60%). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.
AB - Introduction: Non-invasive hemoglobin estimation may increase the recruitment of blood donors. CO-oximetry hemoglobin estimation is a non-invasive method used to estimate the hemoglobin level. The primary objective of this study is to validate the pulse CO-oximetry based hemoglobin estimation in normal blood donors. Methods: We conducted a prospective observational study on 106 in a tertiary care hospital blood bank over a period of 4. weeks. We performed a Spot Hemoglobin concentration (Sp Hb) using Masimo Pronto-7 Pulse CO-oximetry, and compared it to a venous sample Hb concentration (Reference Hemoglobin; Ref Hb) measured using Abbott CELL-DYN Sapphire hematology analyzer. Age, gender, weight, height, blood pressure and reference hemoglobin were used in the multivariable linear regression model of the difference in measurement. Results: Total of 106 donors (98 males, 8 females) were enrolled with a mean age and Ref Hb of 27years (SD 6.2; 18-49) and 14.2g/dL (SD 1.2; 11.5-17) respectively. The mean Sp Hb was 14.4g/dL (SD 1.2;11.3-16.7). The mean difference between the Sp Hb and Ref Hb was 0.2g/dL (SD 1.2;-4.5 to 3) with a correlation coefficient of 0.46 (R2=21%). In the multivariable model, height (p=0.015) and Hb level (p<0.001) were statistically significant predictors. A strong correlation was found between the two CO-oximetry Hb measurements (coefficient 0.78, R2=60%). Conclusions: Our study validated the use of the CO-oximetry in blood donors. Larger prospective studies are needed to confirm our results.
KW - Blood donors
KW - Hemoglobin
KW - Non-invasive
KW - Validation
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U2 - 10.1016/j.transci.2013.10.007
DO - 10.1016/j.transci.2013.10.007
M3 - Article
C2 - 24268769
AN - SCOPUS:84897026681
SN - 1473-0502
VL - 50
SP - 95
EP - 98
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 1
ER -