Utilization patterns of antiepileptic drugs among adult epileptic patients at a tertiary hospital in Oman

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Abstract

Objectives To describe utilization patterns of antiepileptic drugs (AEDs) among adult epileptic patients at a tertiary hospital in Oman. Methods Data were collected retrospectively from January 2006 to December 2009. The study included all adult (>18 years) epileptic patients on AEDs and followed up at a neurology clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic drug monitoring (TDM) requests for serum AED concentrations were also collected. Institutional ethical approval was sought and obtained. Key findings The study included a total of 372 patients with a mean age of 34 ± 15 years. Monotherapy AEDs accounted for 53% of the prescriptions, whereas polytherapy with two or three AED combinations accounted for 27% and 20% respectively. The most frequently prescribed AED was sodium valproate (27%) followed by carbamazepine (23%). The commonly prescribed AED combinations were sodium valproate with clonazepam (12%) followed by sodium valproate with lamotrigine (12%). Evaluation of 574 TDM requests for three AEDs showed that 57% of carbamazepine, 78% of phenytoin and 54% of valproic acid requests were either above or below the recommended therapeutic threshold. Most of these requests were ordered from the hospital's emergency department for suspected insufficient serum concentrations. Conclusions Antiepileptic drug monotherapy is still the most frequently employed therapeutic strategy in adult patients with epilepsy in keeping with the standard therapeutic guidelines. Sodium valproate is commonly used for different types of seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED utilizations are becoming increasingly popular in our subjects particularly as add-on with other standard AEDs.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalInternational Journal of Pharmacy Practice
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Oman
Tertiary Care Centers
Anticonvulsants
Valproic Acid
Drug Monitoring
Carbamazepine
Drug Combinations
Drug Utilization
Clonazepam
Monitoring
Hospital Departments
Phenytoin
Neurology
Serum
Pharmaceutical Preparations
Prescriptions
Hospital Emergency Service
Epilepsy

Keywords

  • antiepileptic drugs
  • epilepsy
  • therapeutic drug monitoring
  • utilization pattern

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Pharmacy

Cite this

@article{19fb32a205f845b7bf105fb40521bc02,
title = "Utilization patterns of antiepileptic drugs among adult epileptic patients at a tertiary hospital in Oman",
abstract = "Objectives To describe utilization patterns of antiepileptic drugs (AEDs) among adult epileptic patients at a tertiary hospital in Oman. Methods Data were collected retrospectively from January 2006 to December 2009. The study included all adult (>18 years) epileptic patients on AEDs and followed up at a neurology clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic drug monitoring (TDM) requests for serum AED concentrations were also collected. Institutional ethical approval was sought and obtained. Key findings The study included a total of 372 patients with a mean age of 34 ± 15 years. Monotherapy AEDs accounted for 53{\%} of the prescriptions, whereas polytherapy with two or three AED combinations accounted for 27{\%} and 20{\%} respectively. The most frequently prescribed AED was sodium valproate (27{\%}) followed by carbamazepine (23{\%}). The commonly prescribed AED combinations were sodium valproate with clonazepam (12{\%}) followed by sodium valproate with lamotrigine (12{\%}). Evaluation of 574 TDM requests for three AEDs showed that 57{\%} of carbamazepine, 78{\%} of phenytoin and 54{\%} of valproic acid requests were either above or below the recommended therapeutic threshold. Most of these requests were ordered from the hospital's emergency department for suspected insufficient serum concentrations. Conclusions Antiepileptic drug monotherapy is still the most frequently employed therapeutic strategy in adult patients with epilepsy in keeping with the standard therapeutic guidelines. Sodium valproate is commonly used for different types of seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED utilizations are becoming increasingly popular in our subjects particularly as add-on with other standard AEDs.",
keywords = "antiepileptic drugs, epilepsy, therapeutic drug monitoring, utilization pattern",
author = "{Al Za'Abi}, Mohammed and Rowayda Ahmed and {Al Asmi}, Abdullah and Ibrahim Al-Zakwani",
year = "2013",
month = "4",
doi = "10.1111/j.2042-7174.2012.00240.x",
language = "English",
volume = "21",
pages = "117--122",
journal = "International Journal of Pharmacy Practice",
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T1 - Utilization patterns of antiepileptic drugs among adult epileptic patients at a tertiary hospital in Oman

AU - Al Za'Abi, Mohammed

AU - Ahmed, Rowayda

AU - Al Asmi, Abdullah

AU - Al-Zakwani, Ibrahim

PY - 2013/4

Y1 - 2013/4

N2 - Objectives To describe utilization patterns of antiepileptic drugs (AEDs) among adult epileptic patients at a tertiary hospital in Oman. Methods Data were collected retrospectively from January 2006 to December 2009. The study included all adult (>18 years) epileptic patients on AEDs and followed up at a neurology clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic drug monitoring (TDM) requests for serum AED concentrations were also collected. Institutional ethical approval was sought and obtained. Key findings The study included a total of 372 patients with a mean age of 34 ± 15 years. Monotherapy AEDs accounted for 53% of the prescriptions, whereas polytherapy with two or three AED combinations accounted for 27% and 20% respectively. The most frequently prescribed AED was sodium valproate (27%) followed by carbamazepine (23%). The commonly prescribed AED combinations were sodium valproate with clonazepam (12%) followed by sodium valproate with lamotrigine (12%). Evaluation of 574 TDM requests for three AEDs showed that 57% of carbamazepine, 78% of phenytoin and 54% of valproic acid requests were either above or below the recommended therapeutic threshold. Most of these requests were ordered from the hospital's emergency department for suspected insufficient serum concentrations. Conclusions Antiepileptic drug monotherapy is still the most frequently employed therapeutic strategy in adult patients with epilepsy in keeping with the standard therapeutic guidelines. Sodium valproate is commonly used for different types of seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED utilizations are becoming increasingly popular in our subjects particularly as add-on with other standard AEDs.

AB - Objectives To describe utilization patterns of antiepileptic drugs (AEDs) among adult epileptic patients at a tertiary hospital in Oman. Methods Data were collected retrospectively from January 2006 to December 2009. The study included all adult (>18 years) epileptic patients on AEDs and followed up at a neurology clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic drug monitoring (TDM) requests for serum AED concentrations were also collected. Institutional ethical approval was sought and obtained. Key findings The study included a total of 372 patients with a mean age of 34 ± 15 years. Monotherapy AEDs accounted for 53% of the prescriptions, whereas polytherapy with two or three AED combinations accounted for 27% and 20% respectively. The most frequently prescribed AED was sodium valproate (27%) followed by carbamazepine (23%). The commonly prescribed AED combinations were sodium valproate with clonazepam (12%) followed by sodium valproate with lamotrigine (12%). Evaluation of 574 TDM requests for three AEDs showed that 57% of carbamazepine, 78% of phenytoin and 54% of valproic acid requests were either above or below the recommended therapeutic threshold. Most of these requests were ordered from the hospital's emergency department for suspected insufficient serum concentrations. Conclusions Antiepileptic drug monotherapy is still the most frequently employed therapeutic strategy in adult patients with epilepsy in keeping with the standard therapeutic guidelines. Sodium valproate is commonly used for different types of seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED utilizations are becoming increasingly popular in our subjects particularly as add-on with other standard AEDs.

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