utilization pattern of anti-depressants at a tertiary hospital in Oman

A retrospective analysis

Mohammed Al Za'abi, Asaad S. Al Jabri, Jabran K. Al Bartamani

Research output: Contribution to journalArticle

Abstract

Introduction: Antidepressants play a major role in managing depression and other conditions. The use of various classes of antidepressants varies from a country to another but information about the use of these agents in the developing countries is scarce. Objective: To assess the use of different classes of antidepressant medications in a tertiary hospital in Oman. Method: Data over four month period (January to April 2013) were retrieved retrospectively after obtaining ethical approval. Results: A total number of 1416 prescriptions were analyzed. Of these 880 (62.1%) were for females and 536 (37.9%) were for males. Tricyclic antidepressant (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs) and mirtazapine accounted for 34.6%, 32.1%, 13.3% and 19.9% of prescriptions, respectively. Monotherapy accounted for 89.3% of prescriptions. The most used single antidepressant drug was amitriptyline (28.5%) followed by mirtazapine (19.9%) and paroxetine (17.9%). SSRIs, SNRIs and mirtazapine were mainly used for psychiatric conditions in 82.2%, 73.0% and 68.8% of the cases, respectively, while TCAs were mainly indicated (63.7%) for non-psychiatric conditions. Conclusion: Monotherapy antidepressant is the preferred mode of therapy with SSRIs and mirtazapine as first line therapy for depression which is consistent with therapeutic guidelines recommendations.

Original languageEnglish
Article number1000163
JournalAfrican Journal of Psychiatry (South Africa)
Volume17
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Oman
Tertiary Care Centers
Antidepressive Agents
Serotonin Uptake Inhibitors
Prescriptions
Tricyclic Antidepressive Agents
Paroxetine
Amitriptyline
Developing Countries
Psychiatry
Therapeutics
Guidelines
mirtazapine

Keywords

  • Amitriptyline
  • Antidepressants
  • Depression
  • Mirtazapine

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

utilization pattern of anti-depressants at a tertiary hospital in Oman : A retrospective analysis. / Al Za'abi, Mohammed; Al Jabri, Asaad S.; Al Bartamani, Jabran K.

In: African Journal of Psychiatry (South Africa), Vol. 17, No. 6, 1000163, 2014.

Research output: Contribution to journalArticle

@article{f17a8609bd0541c095747ec69186f812,
title = "utilization pattern of anti-depressants at a tertiary hospital in Oman: A retrospective analysis",
abstract = "Introduction: Antidepressants play a major role in managing depression and other conditions. The use of various classes of antidepressants varies from a country to another but information about the use of these agents in the developing countries is scarce. Objective: To assess the use of different classes of antidepressant medications in a tertiary hospital in Oman. Method: Data over four month period (January to April 2013) were retrieved retrospectively after obtaining ethical approval. Results: A total number of 1416 prescriptions were analyzed. Of these 880 (62.1{\%}) were for females and 536 (37.9{\%}) were for males. Tricyclic antidepressant (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs) and mirtazapine accounted for 34.6{\%}, 32.1{\%}, 13.3{\%} and 19.9{\%} of prescriptions, respectively. Monotherapy accounted for 89.3{\%} of prescriptions. The most used single antidepressant drug was amitriptyline (28.5{\%}) followed by mirtazapine (19.9{\%}) and paroxetine (17.9{\%}). SSRIs, SNRIs and mirtazapine were mainly used for psychiatric conditions in 82.2{\%}, 73.0{\%} and 68.8{\%} of the cases, respectively, while TCAs were mainly indicated (63.7{\%}) for non-psychiatric conditions. Conclusion: Monotherapy antidepressant is the preferred mode of therapy with SSRIs and mirtazapine as first line therapy for depression which is consistent with therapeutic guidelines recommendations.",
keywords = "Amitriptyline, Antidepressants, Depression, Mirtazapine",
author = "{Al Za'abi}, Mohammed and {Al Jabri}, {Asaad S.} and {Al Bartamani}, {Jabran K.}",
year = "2014",
doi = "10.4172/Psychiatry.1000163",
language = "English",
volume = "17",
journal = "South African Psychiatry Review",
issn = "1994-8220",
publisher = "In House Publications",
number = "6",

}

TY - JOUR

T1 - utilization pattern of anti-depressants at a tertiary hospital in Oman

T2 - A retrospective analysis

AU - Al Za'abi, Mohammed

AU - Al Jabri, Asaad S.

AU - Al Bartamani, Jabran K.

PY - 2014

Y1 - 2014

N2 - Introduction: Antidepressants play a major role in managing depression and other conditions. The use of various classes of antidepressants varies from a country to another but information about the use of these agents in the developing countries is scarce. Objective: To assess the use of different classes of antidepressant medications in a tertiary hospital in Oman. Method: Data over four month period (January to April 2013) were retrieved retrospectively after obtaining ethical approval. Results: A total number of 1416 prescriptions were analyzed. Of these 880 (62.1%) were for females and 536 (37.9%) were for males. Tricyclic antidepressant (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs) and mirtazapine accounted for 34.6%, 32.1%, 13.3% and 19.9% of prescriptions, respectively. Monotherapy accounted for 89.3% of prescriptions. The most used single antidepressant drug was amitriptyline (28.5%) followed by mirtazapine (19.9%) and paroxetine (17.9%). SSRIs, SNRIs and mirtazapine were mainly used for psychiatric conditions in 82.2%, 73.0% and 68.8% of the cases, respectively, while TCAs were mainly indicated (63.7%) for non-psychiatric conditions. Conclusion: Monotherapy antidepressant is the preferred mode of therapy with SSRIs and mirtazapine as first line therapy for depression which is consistent with therapeutic guidelines recommendations.

AB - Introduction: Antidepressants play a major role in managing depression and other conditions. The use of various classes of antidepressants varies from a country to another but information about the use of these agents in the developing countries is scarce. Objective: To assess the use of different classes of antidepressant medications in a tertiary hospital in Oman. Method: Data over four month period (January to April 2013) were retrieved retrospectively after obtaining ethical approval. Results: A total number of 1416 prescriptions were analyzed. Of these 880 (62.1%) were for females and 536 (37.9%) were for males. Tricyclic antidepressant (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs) and mirtazapine accounted for 34.6%, 32.1%, 13.3% and 19.9% of prescriptions, respectively. Monotherapy accounted for 89.3% of prescriptions. The most used single antidepressant drug was amitriptyline (28.5%) followed by mirtazapine (19.9%) and paroxetine (17.9%). SSRIs, SNRIs and mirtazapine were mainly used for psychiatric conditions in 82.2%, 73.0% and 68.8% of the cases, respectively, while TCAs were mainly indicated (63.7%) for non-psychiatric conditions. Conclusion: Monotherapy antidepressant is the preferred mode of therapy with SSRIs and mirtazapine as first line therapy for depression which is consistent with therapeutic guidelines recommendations.

KW - Amitriptyline

KW - Antidepressants

KW - Depression

KW - Mirtazapine

UR - http://www.scopus.com/inward/record.url?scp=84928154982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928154982&partnerID=8YFLogxK

U2 - 10.4172/Psychiatry.1000163

DO - 10.4172/Psychiatry.1000163

M3 - Article

VL - 17

JO - South African Psychiatry Review

JF - South African Psychiatry Review

SN - 1994-8220

IS - 6

M1 - 1000163

ER -