utilization pattern of anti-depressants at a tertiary hospital in Oman: A retrospective analysis

Mohammed Al Za'abi, Asaad S. Al Jabri, Jabran K. Al Bartamani

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Abstract

Introduction: Antidepressants play a major role in managing depression and other conditions. The use of various classes of antidepressants varies from a country to another but information about the use of these agents in the developing countries is scarce. Objective: To assess the use of different classes of antidepressant medications in a tertiary hospital in Oman. Method: Data over four month period (January to April 2013) were retrieved retrospectively after obtaining ethical approval. Results: A total number of 1416 prescriptions were analyzed. Of these 880 (62.1%) were for females and 536 (37.9%) were for males. Tricyclic antidepressant (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs) and mirtazapine accounted for 34.6%, 32.1%, 13.3% and 19.9% of prescriptions, respectively. Monotherapy accounted for 89.3% of prescriptions. The most used single antidepressant drug was amitriptyline (28.5%) followed by mirtazapine (19.9%) and paroxetine (17.9%). SSRIs, SNRIs and mirtazapine were mainly used for psychiatric conditions in 82.2%, 73.0% and 68.8% of the cases, respectively, while TCAs were mainly indicated (63.7%) for non-psychiatric conditions. Conclusion: Monotherapy antidepressant is the preferred mode of therapy with SSRIs and mirtazapine as first line therapy for depression which is consistent with therapeutic guidelines recommendations.

Original languageEnglish
Article number1000163
JournalAfrican Journal of Psychiatry (South Africa)
Volume17
Issue number6
DOIs
Publication statusPublished - 2014

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Keywords

  • Amitriptyline
  • Antidepressants
  • Depression
  • Mirtazapine

ASJC Scopus subject areas

  • Psychiatry and Mental health

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