TY - GEN
T1 - Using ANN and MPC to optimize acoustically assisted Doxorubicin release from micelles
AU - Husseini, Ghaleb A.
AU - Mjalli, Farouq S.
AU - Pitt, William G.
AU - Abdel-Jabbar, Nabil M.
PY - 2009
Y1 - 2009
N2 - We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target drug release at the tumor site via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking. We were successful in designing and testing a controller capable of adjusting the ultrasound frequency, intensity, and pulse length to sustain constant Dox release.
AB - We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target drug release at the tumor site via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking. We were successful in designing and testing a controller capable of adjusting the ultrasound frequency, intensity, and pulse length to sustain constant Dox release.
KW - Artificial neural network
KW - Continuous and pulsed ultrasound
KW - Doxorubicin
KW - Drug release
KW - Model predictive control
KW - Polymeric micelles
UR - http://www.scopus.com/inward/record.url?scp=74549208031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74549208031&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:74549208031
SN - 9780889867994
T3 - Proceedings of the IASTED International Conference on Modelling and Simulation
SP - 320
EP - 325
BT - Proceedings of the 20th IASTED International Conference on Modelling and Simulation, MS 2009
T2 - 20th IASTED International Conference on Modelling and Simulation, MS 2009
Y2 - 6 July 2009 through 8 July 2009
ER -
