Use of XAS for the elucidation of metal structure and function: Applications to nickel biochemistry, molecular toxicology, and carcinogenesis

Paul E. Carrington, Faizah Al-Mjeni, Maria A. Zoroddu, Max Costa, Michael J. Maroney

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Nickel has been shown to be an essential trace element involved in the metabolism of several species of bacteria, archea, and plants. In these organisms, nickel is involved in enzymes that catalyze both non-redox (e.g., urease, glyoxalase I) and redox (e.g., hydrogenase, carbon monoxide dehydrogenase, superoxide dismutase) reactions, and proteins involved in the transprt, strage, metallocenter assembly, and regulation of nickel concentration have evolved. Studies of structure/function relationship in nickel biochemistry reveal that cysteine ligands are used to stabilize the Ni(III/II) redox couple. Certain nickel compounds have also been shown to be potent human carcinogens. A likely target for carcinogenic nickel -is nuclear histone proteins. Here we present X-ray absorption spectroscopic studies of a model Ni peptide designed to help characterize the structure of the nickel complexes formed with histones and place them in the context of nickel structure/function relationships, to gain insights into the molecular mechanism of nickel carcinogenesis.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalEnvironmental Health Perspectives
Volume110
Issue numberSUPPL. 5
Publication statusPublished - Oct 2002

Fingerprint

Nickel
Biochemistry
Toxicology
Carcinogenesis
Metals
carbon monoxide dehydrogenase
Histones
Oxidation-Reduction
Lactoylglutathione Lyase
Hydrogenase
Urease
Archaea
Trace Elements
Nuclear Proteins
Carcinogens
Superoxide Dismutase
Cysteine
X-Rays
Ligands
Bacteria

Keywords

  • Carcinogenesis
  • Enzyme
  • Histone
  • Nickel
  • Nucleosome
  • Protein
  • XAS

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Use of XAS for the elucidation of metal structure and function : Applications to nickel biochemistry, molecular toxicology, and carcinogenesis. / Carrington, Paul E.; Al-Mjeni, Faizah; Zoroddu, Maria A.; Costa, Max; Maroney, Michael J.

In: Environmental Health Perspectives, Vol. 110, No. SUPPL. 5, 10.2002, p. 705-708.

Research output: Contribution to journalArticle

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