An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.
- Palladium complexation
- Sequential injection analysis
ASJC Scopus subject areas
- Analytical Chemistry