Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid

Salah M. Sultan; Fakhr Eldin O. Suliman; Bahruddin B. Saad

doi:10.1039/AN9952000561

Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid

Salah M. Sultan^*, Fakhr Eldin O. Suliman, Bahruddin B. Saad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s^-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10^-3 moll^-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10^-3 mol l^-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

Original language	English
Pages (from-to)	561-563
Number of pages	3
Journal	The Analyst
Volume	120
Issue number	2
DOIs	https://doi.org/10.1039/AN9952000561
Publication status	Published - 1995
Externally published	Yes

Keywords

Palladium complexation
Perphenazine
Sequential injection analysis
Stoichiometry
Trimeprazine

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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10.1039/AN9952000561

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title = "Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid",

abstract = "An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.",

keywords = "Palladium complexation, Perphenazine, Sequential injection analysis, Stoichiometry, Trimeprazine",

author = "Sultan, {Salah M.} and Suliman, {Fakhr Eldin O.} and Saad, {Bahruddin B.}",

year = "1995",

doi = "10.1039/AN9952000561",

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pages = "561--563",

journal = "The Analyst",

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publisher = "Royal Society of Chemistry",

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T1 - Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid

AU - Sultan, Salah M.

AU - Suliman, Fakhr Eldin O.

AU - Saad, Bahruddin B.

PY - 1995

Y1 - 1995

N2 - An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

AB - An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

KW - Palladium complexation

KW - Perphenazine

KW - Sequential injection analysis

KW - Stoichiometry

KW - Trimeprazine

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DO - 10.1039/AN9952000561

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JO - The Analyst

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ER -

Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid

Abstract

Keywords

ASJC Scopus subject areas

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