Use of the sequential injection technique to determine the concentrations and stoichiometries of trimeprazine and perphenazine complexed with palladium(II) in hydrochloric acid

Salah M. Sultan, Fakhr Eldin O Suliman, Bahruddin B. Saad

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

Original languageEnglish
Pages (from-to)561-563
Number of pages3
JournalAnalyst
Volume120
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Trimeprazine
Perphenazine
Hydrochloric Acid
palladium
Palladium
hydrochloric acid
Hydrochloric acid
stoichiometry
Stoichiometry
Injections
Biometry
Monitoring
biometry
monitoring
Complexation
complexation
Drug products
drug
Pharmaceutical Preparations
method

Keywords

  • Palladium complexation
  • Perphenazine
  • Sequential injection analysis
  • Stoichiometry
  • Trimeprazine

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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abstract = "An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.",
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AU - Sultan, Salah M.

AU - Suliman, Fakhr Eldin O

AU - Saad, Bahruddin B.

PY - 1995

Y1 - 1995

N2 - An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

AB - An automated method for the determination of trimeprazine and perphenazine by complexation with palladium(II) in hydrochloric acid was developed. A sequential injection technique with a flow reversal of 29.4 s-1 and a measuring cycle of 73 s was used. Trimeprazine in the range 50-400 ppm was determined at pH 4.7 using 5.0 × 10-3 moll-1 palladium(II) solution and monitoring the product spectrophotometrically at 515 nm. Perphenazine in the range 50-500 ppm was determined at pH 4.85 using 2.5 × 10-3 mol l-1 palladium(II) solution and monitoring the product at 560 nm. The technique was successfully applied to the determination of reaction stoic-biometry. Interferences were studied and the method was found to be suitable for the determination of the two compounds in pharmaceutical preparations.

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KW - Sequential injection analysis

KW - Stoichiometry

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