Abstract
The large intestine is a home for trillions of microbiota, which confer many benefits on the host, including production of vitamins, absorption of nutrients, pathogen displacement, and development of the immune system. For several decades, germ-free animals have been used to study the interaction between the host and its microbiota. This minireview describes the technical aspects for establishing and maintaining germ-free animals and highlights the advantages and disadvantages for germ-free animals as experimental models.
Original language | English |
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Article number | A001 |
Pages (from-to) | 1583-1588 |
Number of pages | 6 |
Journal | Journal of Microbiology and Biotechnology |
Volume | 25 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Germ-free animals
- Germ-free mice
- Gnotobiotic
- Isolator technology
- Microbiota
ASJC Scopus subject areas
- Biotechnology
- Applied Microbiology and Biotechnology