Use of colony stimulating factors in acute myeloid leukaemia

A case control study

Ikram A. Burney, Ghulam N. Kakepoto, Kashif H. Qureshi, Man E. Chandna, Salman N. Adil, Tariq Siddiqui, Mohammed Khurshid

Research output: Contribution to journalArticle

Abstract

Haematopoietic growth factors including granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) are increasingly being used in acute myeloid leukaemia (AML) but with some concern about the possibility of causing proliferation of leukaemic cells. The growth factors are reported to reduce the duration of neutropenia and incidence of infection in neutropenic patients and to increase the disease-free survival of patients with acute myeloid leukaemia. We studied 32 episodes of neutropenia in patients with AML following chemotherapy with G-CSF and GM-CSF. Comparison with historical controls showed a significant reduction in infection and morbidity but no difference in duration of neutropenia or antibiotic usage. We conclude that growth factors can be used in AML in our setting with the aim of reducing septic deaths and morbidity. (C) 2000 Science Reviews.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalMedical Science Research
Volume28
Issue number2
Publication statusPublished - 2000

Fingerprint

Colony-Stimulating Factors
Acute Myeloid Leukemia
Case-Control Studies
Intercellular Signaling Peptides and Proteins
Neutropenia
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Chemotherapy
Morbidity
Infection
Anti-Bacterial Agents
Disease-Free Survival
Cell Proliferation
Drug Therapy
Incidence

Keywords

  • Acute myeloid leukaemia
  • Colony stimulating factors
  • Febrile neutropenia

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Burney, I. A., Kakepoto, G. N., Qureshi, K. H., Chandna, M. E., Adil, S. N., Siddiqui, T., & Khurshid, M. (2000). Use of colony stimulating factors in acute myeloid leukaemia: A case control study. Medical Science Research, 28(2), 105-107.

Use of colony stimulating factors in acute myeloid leukaemia : A case control study. / Burney, Ikram A.; Kakepoto, Ghulam N.; Qureshi, Kashif H.; Chandna, Man E.; Adil, Salman N.; Siddiqui, Tariq; Khurshid, Mohammed.

In: Medical Science Research, Vol. 28, No. 2, 2000, p. 105-107.

Research output: Contribution to journalArticle

Burney, IA, Kakepoto, GN, Qureshi, KH, Chandna, ME, Adil, SN, Siddiqui, T & Khurshid, M 2000, 'Use of colony stimulating factors in acute myeloid leukaemia: A case control study', Medical Science Research, vol. 28, no. 2, pp. 105-107.
Burney IA, Kakepoto GN, Qureshi KH, Chandna ME, Adil SN, Siddiqui T et al. Use of colony stimulating factors in acute myeloid leukaemia: A case control study. Medical Science Research. 2000;28(2):105-107.
Burney, Ikram A. ; Kakepoto, Ghulam N. ; Qureshi, Kashif H. ; Chandna, Man E. ; Adil, Salman N. ; Siddiqui, Tariq ; Khurshid, Mohammed. / Use of colony stimulating factors in acute myeloid leukaemia : A case control study. In: Medical Science Research. 2000 ; Vol. 28, No. 2. pp. 105-107.
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