Use of a sequential injection technique for mechanistic studies and kinetic determination of bromazepam complexed with iron(II) in hydrochloric acid

Salah M. Sultan, F. E O Suliman

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15 Citations (Scopus)


For the first time a sequential injection technique has been employed in a full kinetic investigation as well as for a kinetic procedure utilizing the fixed-time method. The complexation reaction of bromazepam with iron(II) in hydrochloric acid was studied using spectrophotometric detection at λ(max) 585 nm for the product formed. A rate law was offered, which was found to be consistent with the postulated reaction mechanism. From the observed kinetics it was found that the fixed-time method utilized at 100 s using 0.0100 mol dm-3 iron(II) and 0.0115 mol dm-3 HCl had optimal conditions for the determination of bromazepam in the range 5.0 x 10-4-1.5 x 10-3 mol dm-3. The method was found to be suitable for the determination of bromazepam in drug formulations.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
Issue number5
Publication statusPublished - May 1996



  • Bromazepam
  • Fixed-time method
  • Iron(II)
  • Kinetics
  • Reaction mechanism
  • Sequential injection

ASJC Scopus subject areas

  • Analytical Chemistry

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