Urinary vascular cell adhesion molecule-1 as a marker of disease activity in lupus nephritis

Shivraj Padiyar, Theophilus Vijayakumar, Samuel Hansdak, John Mathew*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The objective of this study is to study the role of urinary vascular cell adhesion molecule-1 (uVCAM-1) as a marker for disease activity in lupus nephritis (LN). Methodology: This was a diagnostic study where patients with active LN were taken as cases and those without LN were taken as disease controls. uVCAM-1 was correlated with the classes of LN and standard of care markers. Results: There was a significant difference between the uVCAM-1 values in cases (59.69 [range: 0.07-13752.5]) pg/mg and controls (2.11 [range - 0.11 - 1138.5] pg/mg [P = 0.02]). Maximum levels of VCAM 1 were seen in Class 4 and Class 5 LN (P = 0.96). Although higher renal systemic lupus erythematosus disease activity index score had a higher median value of uVCAM 1, the values were not statistically significant (P = 0.2). There is a positive correlation between the uVCAM1 and anti-double-stranded DNA (anti-dsDNA) levels (r = 0.38) and a negative correlation between VCAM 1 levels and C3 (r = -0.19).The sensitivity of uVCAM1 for determining the disease activity was 65.2%, and the specificity was 75% at a cutoff value of more than 23.8 pg/mg. Conclusions: uVCAM 1, although not in isolation, but along with the other standard of care markers may be useful in assessing the disease activity.

Original languageEnglish
Pages (from-to)396-401
Number of pages6
JournalIndian Journal of Rheumatology
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 2021
Externally publishedYes

Keywords

  • Activity
  • biomarker
  • lupus nephritis
  • systemic lupus erythematosus disease activity index
  • urinary vascular cell adhesion molecule-11

ASJC Scopus subject areas

  • Rheumatology

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