Unmasking immune reconstitution inflammatory syndrome (IRIS)

A report of five cases and review of the literature

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Immune reconstitution inflammatory syndromes (IRIS) in patients with acquired immune deficiency syndrome (AIDS) are characterised by atypical manifestations of opportunistic pathogens. These occur in patients experiencing improvement in CD4 cell counts following receipt of highly active anti-retroviral therapy (HAART). Although well established as a syndrome, IRIS still presents challenges in diagnosis and management. We report five cases of IRIS with diverse clinical presentations and due to different infectious aetiologies. A review of the published literature on this syndrome is also included.

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalSultan Qaboos University Medical Journal
Volume11
Issue number1
Publication statusPublished - Feb 2011

Fingerprint

Immune Reconstitution Inflammatory Syndrome
CD4 Lymphocyte Count
Acquired Immunodeficiency Syndrome
Therapeutics

Keywords

  • AIDS
  • Atypical mycobacterium
  • Case report
  • Cryptococcus
  • Cryptosporidium
  • HAART
  • HIV
  • Immune reconstitution inflammatory syndrome
  • IRIS
  • Oman
  • TB
  • Toxoplasmosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Unmasking immune reconstitution inflammatory syndrome (IRIS): A report of five cases and review of the literature",
abstract = "Immune reconstitution inflammatory syndromes (IRIS) in patients with acquired immune deficiency syndrome (AIDS) are characterised by atypical manifestations of opportunistic pathogens. These occur in patients experiencing improvement in CD4 cell counts following receipt of highly active anti-retroviral therapy (HAART). Although well established as a syndrome, IRIS still presents challenges in diagnosis and management. We report five cases of IRIS with diverse clinical presentations and due to different infectious aetiologies. A review of the published literature on this syndrome is also included.",
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