Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalFrontiers in Bioscience - Elite
Volume7
Publication statusPublished - 2015

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Proto-Oncogene Proteins c-pim-1
Prostatic Neoplasms
Burkitt Lymphoma
Mouth Neoplasms
Protein-Serine-Threonine Kinases
Tumors
Lymphoma
Neoplasms
Cell Cycle
Genes
Cells
Apoptosis
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ouhtit, A., Muzumdar, S., Gupta, I., Shanmuganathan, S., & Tamimi, Y. (2015). Understanding the functional discrepancy of Pim-1 in cancer. Frontiers in Bioscience - Elite, 7, 208-214.

Understanding the functional discrepancy of Pim-1 in cancer. / Ouhtit, Allal; Muzumdar, Sukalp; Gupta, Ishita; Shanmuganathan, Somya; Tamimi, Yahya.

In: Frontiers in Bioscience - Elite, Vol. 7, 2015, p. 208-214.

Research output: Contribution to journalArticle

Ouhtit, A, Muzumdar, S, Gupta, I, Shanmuganathan, S & Tamimi, Y 2015, 'Understanding the functional discrepancy of Pim-1 in cancer', Frontiers in Bioscience - Elite, vol. 7, pp. 208-214.
Ouhtit A, Muzumdar S, Gupta I, Shanmuganathan S, Tamimi Y. Understanding the functional discrepancy of Pim-1 in cancer. Frontiers in Bioscience - Elite. 2015;7:208-214.
Ouhtit, Allal ; Muzumdar, Sukalp ; Gupta, Ishita ; Shanmuganathan, Somya ; Tamimi, Yahya. / Understanding the functional discrepancy of Pim-1 in cancer. In: Frontiers in Bioscience - Elite. 2015 ; Vol. 7. pp. 208-214.
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