Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit; Sukalp Muzumdar; Ishita Gupta; Somya Shanmuganathan; Yahya Tamimi

Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit^*, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (SciVal)

Abstract

The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Original language	English
Pages (from-to)	239-247
Number of pages	9
Journal	Frontiers in Bioscience - Elite
Volume	7
Publication status	Published - Jan 15 2015

Keywords

CAMKs
Inhibitors
Pim-1 kinase
Prostate cancer
Review

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.",

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T1 - Understanding the functional discrepancy of Pim-1 in cancer

AU - Ouhtit, Allal

AU - Muzumdar, Sukalp

AU - Gupta, Ishita

AU - Shanmuganathan, Somya

AU - Tamimi, Yahya

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

AB - The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

KW - CAMKs

KW - Inhibitors

KW - Pim-1 kinase

KW - Prostate cancer

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=84919372532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919372532&partnerID=8YFLogxK

M3 - Review article

C2 - 25553374

AN - SCOPUS:84941746835

SN - 1945-0494

VL - 7

SP - 239

EP - 247

JO - Frontiers in Bioscience - Elite

JF - Frontiers in Bioscience - Elite

ER -

Understanding the functional discrepancy of Pim-1 in cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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