Understanding discrepancy in autism epidemiology in view of underpinning genetic architecture: Lessons learnt from studies in consanguineous populations

Ahmed B. Idris*, Watfa Al-Mamari, Reem Abdulrahim, Abeer Alsayegh

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract

This short commentary aims to shed light on the discrepancy in the epidemiological findings and underlying genetic architecture of Autism Spectrum Disorder (ASD) between demographically distinct populations; consanguineous and non-consanguineous. Here we discuss the effect of advanced paternal age as a risk factor acting as a proxy for potential underlying genetic mechanisms. On that account, this narrative postulates that disparity might possibly be explained in the context of the differences in genetic makeup and abundance of recessive mutations in the highly consanguineous populations.

Original languageEnglish
Article number101944
JournalResearch in Autism Spectrum Disorders
Volume93
DOIs
Publication statusPublished - May 2022

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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