TY - JOUR
T1 - Understanding discrepancy in autism epidemiology in view of underpinning genetic architecture
T2 - Lessons learnt from studies in consanguineous populations
AU - Idris, Ahmed B.
AU - Al-Mamari, Watfa
AU - Abdulrahim, Reem
AU - Alsayegh, Abeer
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/5/1
Y1 - 2022/5/1
N2 - This short commentary aims to shed light on the discrepancy in the epidemiological findings and underlying genetic architecture of Autism Spectrum Disorder (ASD) between demographically distinct populations; consanguineous and non-consanguineous. Here we discuss the effect of advanced paternal age as a risk factor acting as a proxy for potential underlying genetic mechanisms. On that account, this narrative postulates that disparity might possibly be explained in the context of the differences in genetic makeup and abundance of recessive mutations in the highly consanguineous populations.
AB - This short commentary aims to shed light on the discrepancy in the epidemiological findings and underlying genetic architecture of Autism Spectrum Disorder (ASD) between demographically distinct populations; consanguineous and non-consanguineous. Here we discuss the effect of advanced paternal age as a risk factor acting as a proxy for potential underlying genetic mechanisms. On that account, this narrative postulates that disparity might possibly be explained in the context of the differences in genetic makeup and abundance of recessive mutations in the highly consanguineous populations.
UR - http://www.scopus.com/inward/record.url?scp=85125482293&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85125482293&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/95609233-8554-368c-bd5b-c1dfd7f9074b/
U2 - 10.1016/j.rasd.2022.101944
DO - 10.1016/j.rasd.2022.101944
M3 - Comment/debate
AN - SCOPUS:85125482293
SN - 1750-9467
VL - 93
JO - Research in Autism Spectrum Disorders
JF - Research in Autism Spectrum Disorders
M1 - 101944
ER -
