Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births

Kanjaksha Ghosh, Dilip Yavagal, Callista Phillips, Farah Jijina, A. V. Pathare, Lily Kerketta, Y. S. Iyer, C. N. Nair, S. Shinde, Dipika Mohanty

Research output: Contribution to journalArticle

Abstract

A 28 year old female patient presented with refractory anaemia since childhood and recurrent still-births at 28-30 weeks of gestation. One still-born child was hydropic at birth. Bone marrow showed characteristic morphological changes of congenital dyserythropoietic anaemia (CDA)-Type III. Electron microscopy showed disruption of the nuclear membrane, spongy appearance of nuclei, stacks of microtubules in intermediate normoblasts and myelin figures in erythroid cells. In vitro culture and karyotype data from the bone marrow of the patient is presented. Recurrent still-births in association with congenital dyserythropoietic anaemia has rarely been reported in the literature.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalHaematologia
Volume29
Issue number1
Publication statusPublished - 1998

Keywords

  • BFU-E
  • Dyserythropoiesis
  • Gigantoblasts
  • Hyperploidy
  • Microtubules

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births'. Together they form a unique fingerprint.

  • Cite this

    Ghosh, K., Yavagal, D., Phillips, C., Jijina, F., Pathare, A. V., Kerketta, L., Iyer, Y. S., Nair, C. N., Shinde, S., & Mohanty, D. (1998). Ultrastructural, cell culture and karyotype study of bone marrow in a patient with congenital dyserythropoietic anaemia (CDA)-type III presenting with recurrent still-births. Haematologia, 29(1), 41-45.