Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

E. Zeggini, W. Thomson, A. Alansari, W. Ollier, R. Donn, M. Abinun, M. Becker, A. Bell, A. Craft, E. Crawley, J. David, J. Gardener-Medwin, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. Holt, S. Jones, G. Pountain & 7 others C. Ryder, T. Southwood, I. Stewart, P. Woo, S. Wyatt, H. Venning, The British paediatric Rheumatology Study Group

Research output: Contribution to journalArticle

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Abstract

Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

Original languageEnglish
Pages (from-to)462-465
Number of pages4
JournalRheumatology
Volume41
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Juvenile Arthritis
Tumor Necrosis Factor Receptors
Single Nucleotide Polymorphism
Exons
Restriction Fragment Length Polymorphisms
Tumor Necrosis Factor-alpha
Polymerase Chain Reaction

Keywords

  • Complex genetic disease
  • Juvenile idiopathic arthritis
  • Single nucleotide polymorphism
  • Tumour necrosis factor receptor II

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Zeggini, E., Thomson, W., Alansari, A., Ollier, W., Donn, R., Abinun, M., ... The British paediatric Rheumatology Study Group (2002). Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology, 41(4), 462-465. https://doi.org/10.1093/rheumatology/41.4.462

Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. / Zeggini, E.; Thomson, W.; Alansari, A.; Ollier, W.; Donn, R.; Abinun, M.; Becker, M.; Bell, A.; Craft, A.; Crawley, E.; David, J.; Gardener-Medwin, J.; Griffin, J.; Hall, A.; Hall, M.; Herrick, A.; Hollingworth, P.; Holt, L.; Jones, S.; Pountain, G.; Ryder, C.; Southwood, T.; Stewart, I.; Woo, P.; Wyatt, S.; Venning, H.; The British paediatric Rheumatology Study Group.

In: Rheumatology, Vol. 41, No. 4, 2002, p. 462-465.

Research output: Contribution to journalArticle

Zeggini, E, Thomson, W, Alansari, A, Ollier, W, Donn, R, Abinun, M, Becker, M, Bell, A, Craft, A, Crawley, E, David, J, Gardener-Medwin, J, Griffin, J, Hall, A, Hall, M, Herrick, A, Hollingworth, P, Holt, L, Jones, S, Pountain, G, Ryder, C, Southwood, T, Stewart, I, Woo, P, Wyatt, S, Venning, H & The British paediatric Rheumatology Study Group 2002, 'Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis', Rheumatology, vol. 41, no. 4, pp. 462-465. https://doi.org/10.1093/rheumatology/41.4.462
Zeggini, E. ; Thomson, W. ; Alansari, A. ; Ollier, W. ; Donn, R. ; Abinun, M. ; Becker, M. ; Bell, A. ; Craft, A. ; Crawley, E. ; David, J. ; Gardener-Medwin, J. ; Griffin, J. ; Hall, A. ; Hall, M. ; Herrick, A. ; Hollingworth, P. ; Holt, L. ; Jones, S. ; Pountain, G. ; Ryder, C. ; Southwood, T. ; Stewart, I. ; Woo, P. ; Wyatt, S. ; Venning, H. ; The British paediatric Rheumatology Study Group. / Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. In: Rheumatology. 2002 ; Vol. 41, No. 4. pp. 462-465.
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AU - Thomson, W.

AU - Alansari, A.

AU - Ollier, W.

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AU - Abinun, M.

AU - Becker, M.

AU - Bell, A.

AU - Craft, A.

AU - Crawley, E.

AU - David, J.

AU - Gardener-Medwin, J.

AU - Griffin, J.

AU - Hall, A.

AU - Hall, M.

AU - Herrick, A.

AU - Hollingworth, P.

AU - Holt, L.

AU - Jones, S.

AU - Pountain, G.

AU - Ryder, C.

AU - Southwood, T.

AU - Stewart, I.

AU - Woo, P.

AU - Wyatt, S.

AU - Venning, H.

AU - The British paediatric Rheumatology Study Group

PY - 2002

Y1 - 2002

N2 - Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

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