Triterpenoids from the leaves of Psidium guajava

Sabira Begum; Syed Imran Hassan; Bina S. Siddiqui; Farhana Shaheen; M. Nabeel Ghayur; Anwar H. Gilani

doi:10.1016/S0031-9422(02)00190-5

Triterpenoids from the leaves of Psidium guajava

Sabira Begum^*, Syed Imran Hassan, Bina S. Siddiqui, Farhana Shaheen, M. Nabeel Ghayur, Anwar H. Gilani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

Abstract

Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.

Original language	English
Pages (from-to)	399-403
Number of pages	5
Journal	Phytochemistry
Volume	61
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9422(02)00190-5
Publication status	Published - Oct 2002
Externally published	Yes

Keywords

Guavacoumaric acid
Guavanoic acid
Psidium guajava
Spasmolytic activity
Triterpenoids

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(02)00190-5

Cite this

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title = "Triterpenoids from the leaves of Psidium guajava",

abstract = "Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.",

keywords = "Guavacoumaric acid, Guavanoic acid, Psidium guajava, Spasmolytic activity, Triterpenoids",

author = "Sabira Begum and Hassan, {Syed Imran} and Siddiqui, {Bina S.} and Farhana Shaheen and {Nabeel Ghayur}, M. and Gilani, {Anwar H.}",

year = "2002",

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doi = "10.1016/S0031-9422(02)00190-5",

language = "English",

volume = "61",

pages = "399--403",

journal = "Phytochemistry",

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AU - Begum, Sabira

AU - Hassan, Syed Imran

AU - Siddiqui, Bina S.

AU - Shaheen, Farhana

AU - Nabeel Ghayur, M.

AU - Gilani, Anwar H.

PY - 2002/10

Y1 - 2002/10

N2 - Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.

AB - Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.

KW - Guavacoumaric acid

KW - Guavanoic acid

KW - Psidium guajava

KW - Spasmolytic activity

KW - Triterpenoids

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U2 - 10.1016/S0031-9422(02)00190-5

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C2 - 12377233

AN - SCOPUS:0036774814

SN - 0031-9422

VL - 61

SP - 399

EP - 403

JO - Phytochemistry

JF - Phytochemistry

IS - 4

ER -

Triterpenoids from the leaves of Psidium guajava

Abstract

Keywords

ASJC Scopus subject areas

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