Triterpenoids from the leaves of Psidium guajava

Sabira Begum*, Syed Imran Hassan, Bina S. Siddiqui, Farhana Shaheen, M. Nabeel Ghayur, Anwar H. Gilani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)

Abstract

Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalPhytochemistry
Volume61
Issue number4
DOIs
Publication statusPublished - Oct 2002

Keywords

  • Guavacoumaric acid
  • Guavanoic acid
  • Psidium guajava
  • Spasmolytic activity
  • Triterpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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