Triterpenoids from the leaves of Psidium guajava

Sabira Begum, Syed Imran Hassan, Bina S. Siddiqui, Farhana Shaheen, M. Nabeel Ghayur, Anwar H. Gilani

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Two triterpenoids, 20β-acetoxy-2α,3β-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2α,3β-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2α-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and β-sitosterol-3-O-β-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 μg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalPhytochemistry
Volume61
Issue number4
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Psidium
Psidium guajava
triterpenoids
Parasympatholytics
Acids
acids
leaves
Jejunum
Rabbits
parasympatholytics
sitosterols
jejunum
rabbits
guavanoic acid
guavacoumaric acid
asiatic acid
2-hydroxyursolic acid
gamma-sitosterol

Keywords

  • Guavacoumaric acid
  • Guavanoic acid
  • Psidium guajava
  • Spasmolytic activity
  • Triterpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Cite this

Begum, S., Hassan, S. I., Siddiqui, B. S., Shaheen, F., Nabeel Ghayur, M., & Gilani, A. H. (2002). Triterpenoids from the leaves of Psidium guajava. Phytochemistry, 61(4), 399-403. https://doi.org/10.1016/S0031-9422(02)00190-5

Triterpenoids from the leaves of Psidium guajava. / Begum, Sabira; Hassan, Syed Imran; Siddiqui, Bina S.; Shaheen, Farhana; Nabeel Ghayur, M.; Gilani, Anwar H.

In: Phytochemistry, Vol. 61, No. 4, 10.2002, p. 399-403.

Research output: Contribution to journalArticle

Begum, S, Hassan, SI, Siddiqui, BS, Shaheen, F, Nabeel Ghayur, M & Gilani, AH 2002, 'Triterpenoids from the leaves of Psidium guajava', Phytochemistry, vol. 61, no. 4, pp. 399-403. https://doi.org/10.1016/S0031-9422(02)00190-5
Begum S, Hassan SI, Siddiqui BS, Shaheen F, Nabeel Ghayur M, Gilani AH. Triterpenoids from the leaves of Psidium guajava. Phytochemistry. 2002 Oct;61(4):399-403. https://doi.org/10.1016/S0031-9422(02)00190-5
Begum, Sabira ; Hassan, Syed Imran ; Siddiqui, Bina S. ; Shaheen, Farhana ; Nabeel Ghayur, M. ; Gilani, Anwar H. / Triterpenoids from the leaves of Psidium guajava. In: Phytochemistry. 2002 ; Vol. 61, No. 4. pp. 399-403.
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