Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman

Jacob P. Chacko, Shanmugakonar Muralitharan, Alia Al-Ansari, Khalsa Al-Kharusi, Abdullah Al-Asmi, Chand R. Pratap, Riad Bayoumi

Research output: Contribution to journalArticle

Abstract

Objective: To explore the profile of cytosine/adenine/guanine (CAG) repeat expansion in Omani spinocerebellar ataxia (SCA) patients. Methods: Ten SCA patients attending the Sultan Qaboos University Hospital Neurologic clinics, Al-Khoud, Oman in the 3 years starting from January 2000 were recruited for this study. Genomic DNA was extracted from peripheral blood samples and CAG repeat expansion analysis was carried out by polymerase chain reaction and sequencing, when required. Results: The CAG triplet repeats leading to polyglutamine expansion and neurodegeneration are seen in spinocerebellar ataxias 1, 2, 3, 6, 7 and 17. By using primers for SCA 1, 2, 3 and 7, we found the repeats were in the normal range and triplet repeats do not seem to be a common cause for ataxia in Oman. Conclusion: Spinocerebellar ataxia in Oman has the normal range of CAG repeats for the commonly found SCA1, SCA2, SCA3 and SCA7.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalNeurosciences
Volume10
Issue number1
Publication statusPublished - Jan 2005

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Oman
Spinocerebellar Ataxias
Trinucleotide Repeats
Cytosine
Guanine
Adenine
Reference Values
Ataxia
Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chacko, J. P., Muralitharan, S., Al-Ansari, A., Al-Kharusi, K., Al-Asmi, A., Pratap, C. R., & Bayoumi, R. (2005). Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman. Neurosciences, 10(1), 61-63.

Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman. / Chacko, Jacob P.; Muralitharan, Shanmugakonar; Al-Ansari, Alia; Al-Kharusi, Khalsa; Al-Asmi, Abdullah; Pratap, Chand R.; Bayoumi, Riad.

In: Neurosciences, Vol. 10, No. 1, 01.2005, p. 61-63.

Research output: Contribution to journalArticle

Chacko, JP, Muralitharan, S, Al-Ansari, A, Al-Kharusi, K, Al-Asmi, A, Pratap, CR & Bayoumi, R 2005, 'Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman', Neurosciences, vol. 10, no. 1, pp. 61-63.
Chacko JP, Muralitharan S, Al-Ansari A, Al-Kharusi K, Al-Asmi A, Pratap CR et al. Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman. Neurosciences. 2005 Jan;10(1):61-63.
Chacko, Jacob P. ; Muralitharan, Shanmugakonar ; Al-Ansari, Alia ; Al-Kharusi, Khalsa ; Al-Asmi, Abdullah ; Pratap, Chand R. ; Bayoumi, Riad. / Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman. In: Neurosciences. 2005 ; Vol. 10, No. 1. pp. 61-63.
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