TY - JOUR
T1 - Treatment outcomes 12 months after antiretroviral therapy initiation in Oman
T2 - a nationwide study from the Middle East
AU - Elgalib, A.
AU - Shah, S.
AU - Al-Wahaibi, A.
AU - Al-Habsi, Z.
AU - Al-Fouri, M.
AU - Lau, R.
AU - Al-Kindi, H.
AU - Al-Rawahi, Bader
AU - Al-Abri, S.
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/10/26
Y1 - 2021/10/26
N2 -
ABSTRACTWe used routinely collected programme data on people living with HIV in Oman who started ART in 2014-2018 to assess retention on ART, viral suppression, attrition (mortality or loss to follow-up [LTFU]) and treatment failure (attrition or HIV viral load of > 1000 copies/mL) 12 months after antiretroviral therapy (ART) initiation. We identified 726 patients; 72% were male. Overall, 12 months retention on ART and viral suppression (intention-to-treat [ITT] analysis) were 85.7% and 74.5%, respectively. Attrition occurred in 14.3% (mortality of 7% and LTFU of 7.3%). Retention increased from 78.8% (93/118) to 90.6% (144/159) among patients who started ART in 2014 and 2018, respectively. Similarly, ITT and on-treatment analyses revealed that viral suppression 12 months after ART initiation increased from 57.6% (68/118) and 73.1% (68/93) among patients who initiated therapy in 2014-80.5% (128/159) and 88.8% (128/144) among patients started treatment in 2018, respectively. On multivariate analysis, older age, having "Other" as an HIV risk factor (compared to heterosexual) and receiving HIV care outside the capital Muscat independently predicted both attrition and treatment failure. Our findings have been useful in identifying factors at the individual and programme level that influenced the risk of attrition and treatment failure.
AB -
ABSTRACTWe used routinely collected programme data on people living with HIV in Oman who started ART in 2014-2018 to assess retention on ART, viral suppression, attrition (mortality or loss to follow-up [LTFU]) and treatment failure (attrition or HIV viral load of > 1000 copies/mL) 12 months after antiretroviral therapy (ART) initiation. We identified 726 patients; 72% were male. Overall, 12 months retention on ART and viral suppression (intention-to-treat [ITT] analysis) were 85.7% and 74.5%, respectively. Attrition occurred in 14.3% (mortality of 7% and LTFU of 7.3%). Retention increased from 78.8% (93/118) to 90.6% (144/159) among patients who started ART in 2014 and 2018, respectively. Similarly, ITT and on-treatment analyses revealed that viral suppression 12 months after ART initiation increased from 57.6% (68/118) and 73.1% (68/93) among patients who initiated therapy in 2014-80.5% (128/159) and 88.8% (128/144) among patients started treatment in 2018, respectively. On multivariate analysis, older age, having "Other" as an HIV risk factor (compared to heterosexual) and receiving HIV care outside the capital Muscat independently predicted both attrition and treatment failure. Our findings have been useful in identifying factors at the individual and programme level that influenced the risk of attrition and treatment failure.
KW - ART
KW - HIV
KW - Middle East
KW - Oman
KW - treatment outcome
KW - HIV Infections
KW - Humans
KW - Male
KW - Anti-HIV Agents/therapeutic use
KW - Treatment Outcome
KW - Oman/epidemiology
KW - Female
KW - Retrospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85118302817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118302817&partnerID=8YFLogxK
U2 - 10.1080/09540121.2021.1991880
DO - 10.1080/09540121.2021.1991880
M3 - Article
C2 - 34702098
AN - SCOPUS:85118302817
SN - 0954-0121
VL - 35
SP - 63
EP - 70
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 1
ER -
