Transient myeloproliferative disorder and Down syndrome: Is there a link?

Zenaida S. Reyes, Wafa Bashir, Anil Pathare

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.

Original languageEnglish
Pages (from-to)498-502
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume12
Issue number4
Publication statusPublished - Nov 2012

Fingerprint

Myeloproliferative Disorders
Down Syndrome
Newborn Infant
Karyotyping
Karyotype
Premature Infants
Leukemia
Transient Myeloproliferative Disorder of Down Syndrome

Keywords

  • Acute myelogenous leukemia (AML)
  • Case report
  • Down syndrome
  • Extreme premature
  • GATA1
  • Oman
  • Transient myeloproliferative disorder

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transient myeloproliferative disorder and Down syndrome : Is there a link? / Reyes, Zenaida S.; Bashir, Wafa; Pathare, Anil.

In: Sultan Qaboos University Medical Journal, Vol. 12, No. 4, 11.2012, p. 498-502.

Research output: Contribution to journalArticle

@article{0a5cbf50f373423d8b51ab1156fba0e0,
title = "Transient myeloproliferative disorder and Down syndrome: Is there a link?",
abstract = "An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.",
keywords = "Acute myelogenous leukemia (AML), Case report, Down syndrome, Extreme premature, GATA1, Oman, Transient myeloproliferative disorder",
author = "Reyes, {Zenaida S.} and Wafa Bashir and Anil Pathare",
year = "2012",
month = "11",
language = "English",
volume = "12",
pages = "498--502",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "4",

}

TY - JOUR

T1 - Transient myeloproliferative disorder and Down syndrome

T2 - Is there a link?

AU - Reyes, Zenaida S.

AU - Bashir, Wafa

AU - Pathare, Anil

PY - 2012/11

Y1 - 2012/11

N2 - An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.

AB - An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.

KW - Acute myelogenous leukemia (AML)

KW - Case report

KW - Down syndrome

KW - Extreme premature

KW - GATA1

KW - Oman

KW - Transient myeloproliferative disorder

UR - http://www.scopus.com/inward/record.url?scp=84870656101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870656101&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84870656101

VL - 12

SP - 498

EP - 502

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 4

ER -