Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Arwa Z. Al-Riyami, Sabah Al-Mahrooqi, Sumaiya Al-Hinai, Saif Al-Hosni, Ali Al-Madhani, Shahina Daar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalTransfusion and Apheresis Science
Volume51
Issue number1
DOIs
Publication statusPublished - Aug 1 2014

Fingerprint

beta-Thalassemia
antineoplaston A10
Tertiary Healthcare
Phenotype
Pregnancy
Blood Banks
Splenectomy
Therapeutics
Blood Transfusion
Anemia
Erythrocytes
Antibodies

Keywords

  • Alloimmunization
  • Phenotype
  • Thalassemia Intermedia
  • Transfusion

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Transfusion therapy and alloimmunization in Thalassemia Intermedia : A 10 year experience at a tertiary care university hospital. / Al-Riyami, Arwa Z.; Al-Mahrooqi, Sabah; Al-Hinai, Sumaiya; Al-Hosni, Saif; Al-Madhani, Ali; Daar, Shahina.

In: Transfusion and Apheresis Science, Vol. 51, No. 1, 01.08.2014, p. 42-46.

Research output: Contribution to journalArticle

Al-Riyami, Arwa Z. ; Al-Mahrooqi, Sabah ; Al-Hinai, Sumaiya ; Al-Hosni, Saif ; Al-Madhani, Ali ; Daar, Shahina. / Transfusion therapy and alloimmunization in Thalassemia Intermedia : A 10 year experience at a tertiary care university hospital. In: Transfusion and Apheresis Science. 2014 ; Vol. 51, No. 1. pp. 42-46.
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