Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Arwa Z. Al-Riyami; Sabah Al-Mahrooqi; Sumaiya Al-Hinai; Saif Al-Hosni; Ali Al-Madhani; Shahina Daar

doi:10.1016/j.transci.2014.04.009

Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Arwa Z. Al-Riyami, Sabah Al-Mahrooqi, Sumaiya Al-Hinai, Saif Al-Hosni, Ali Al-Madhani, Shahina Daar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	Transfusion and Apheresis Science
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.transci.2014.04.009
Publication status	Published - Aug 1 2014
Externally published	Yes

Keywords

Alloimmunization
Phenotype
Thalassemia Intermedia
Transfusion

ASJC Scopus subject areas

Hematology

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10.1016/j.transci.2014.04.009

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title = "Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital",

abstract = "Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.",

keywords = "Alloimmunization, Phenotype, Thalassemia Intermedia, Transfusion",

author = "Al-Riyami, {Arwa Z.} and Sabah Al-Mahrooqi and Sumaiya Al-Hinai and Saif Al-Hosni and Ali Al-Madhani and Shahina Daar",

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doi = "10.1016/j.transci.2014.04.009",

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T2 - A 10 year experience at a tertiary care university hospital

AU - Al-Riyami, Arwa Z.

AU - Al-Mahrooqi, Sabah

AU - Al-Hinai, Sumaiya

AU - Al-Hosni, Saif

AU - Al-Madhani, Ali

AU - Daar, Shahina

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.

AB - Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.

KW - Alloimmunization

KW - Phenotype

KW - Thalassemia Intermedia

KW - Transfusion

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Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Abstract

Keywords

ASJC Scopus subject areas

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