Abstract
Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.
| Original language | English |
|---|---|
| Pages (from-to) | 42-46 |
| Number of pages | 5 |
| Journal | Transfusion and Apheresis Science |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 1 2014 |
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Keywords
- Alloimmunization
- Phenotype
- Thalassemia Intermedia
- Transfusion
ASJC Scopus subject areas
- Hematology
- Medicine(all)
Cite this
Transfusion therapy and alloimmunization in Thalassemia Intermedia : A 10 year experience at a tertiary care university hospital. / Al-Riyami, Arwa Z.; Al-Mahrooqi, Sabah; Al-Hinai, Sumaiya; Al-Hosni, Saif; Al-Madhani, Ali; Daar, Shahina.
In: Transfusion and Apheresis Science, Vol. 51, No. 1, 01.08.2014, p. 42-46.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transfusion therapy and alloimmunization in Thalassemia Intermedia
T2 - A 10 year experience at a tertiary care university hospital
AU - Al-Riyami, Arwa Z.
AU - Al-Mahrooqi, Sabah
AU - Al-Hinai, Sumaiya
AU - Al-Hosni, Saif
AU - Al-Madhani, Ali
AU - Daar, Shahina
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.
AB - Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.
KW - Alloimmunization
KW - Phenotype
KW - Thalassemia Intermedia
KW - Transfusion
UR - http://www.scopus.com/inward/record.url?scp=84930041196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930041196&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2014.04.009
DO - 10.1016/j.transci.2014.04.009
M3 - Article
C2 - 24816438
AN - SCOPUS:84930041196
VL - 51
SP - 42
EP - 46
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
SN - 1473-0502
IS - 1
ER -