Transfusion therapy and alloimmunization in Thalassemia Intermedia: A 10 year experience at a tertiary care university hospital

Arwa Z. Al-Riyami, Sabah Al-Mahrooqi, Sumaiya Al-Hinai, Saif Al-Hosni, Ali Al-Madhani, Shahina Daar

Research output: Contribution to journalArticle

6 Citations (Scopus)


Background: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. Study design and methods: Clinical and blood bank records of 37 TI patients were reviewed. Results: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. Conclusion: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalTransfusion and Apheresis Science
Issue number1
Publication statusPublished - Aug 1 2014



  • Alloimmunization
  • Phenotype
  • Thalassemia Intermedia
  • Transfusion

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

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