Transforming growth factor-β2 polymorphism and systemic lupus erythematosus

Aliya Alansari, Ali Hajeer, Lee Suan Teh, Ardeshir Bayat, Anne Mysercough, Ahmet Gül, Murat Inanc, Jose Ordi-Ros, William Ollier

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective. To determine whether transforming growth factor-β2 (TGF-β2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-β is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-β2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-β2 gene has been mapped. Methods. Association studies were performed in 3 case-control populations, from Spain, Turkey, and UK, using a TGF-β2 5′-untranslated region (5′-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in TGF-β2 5′-UTR polymorphism allele frequencies between SLE patients and matched controls in the 3 populations studied. Conclusion. The 4 bp insertion polymorphism within the TGF-β2 gene does not appear to be associated with SLE. However, this does not rule out the possible involvement of TGF-β2 in the disease pathogenesis.

Original languageEnglish
Pages (from-to)1189-1191
Number of pages3
JournalJournal of Rheumatology
Volume29
Issue number6
Publication statusPublished - 2002

Fingerprint

Transforming Growth Factors
Systemic Lupus Erythematosus
5' Untranslated Regions
T-Lymphocytes
Base Pairing
Genes
Turkey
Gene Frequency
Spain
Population
Interleukin-2
Cytokines
Inflammation
Polymerase Chain Reaction
Growth

Keywords

  • Systemic lupus erythematosus
  • Transforming growth factor β2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Alansari, A., Hajeer, A., Teh, L. S., Bayat, A., Mysercough, A., Gül, A., ... Ollier, W. (2002). Transforming growth factor-β2 polymorphism and systemic lupus erythematosus. Journal of Rheumatology, 29(6), 1189-1191.

Transforming growth factor-β2 polymorphism and systemic lupus erythematosus. / Alansari, Aliya; Hajeer, Ali; Teh, Lee Suan; Bayat, Ardeshir; Mysercough, Anne; Gül, Ahmet; Inanc, Murat; Ordi-Ros, Jose; Ollier, William.

In: Journal of Rheumatology, Vol. 29, No. 6, 2002, p. 1189-1191.

Research output: Contribution to journalArticle

Alansari, A, Hajeer, A, Teh, LS, Bayat, A, Mysercough, A, Gül, A, Inanc, M, Ordi-Ros, J & Ollier, W 2002, 'Transforming growth factor-β2 polymorphism and systemic lupus erythematosus', Journal of Rheumatology, vol. 29, no. 6, pp. 1189-1191.
Alansari A, Hajeer A, Teh LS, Bayat A, Mysercough A, Gül A et al. Transforming growth factor-β2 polymorphism and systemic lupus erythematosus. Journal of Rheumatology. 2002;29(6):1189-1191.
Alansari, Aliya ; Hajeer, Ali ; Teh, Lee Suan ; Bayat, Ardeshir ; Mysercough, Anne ; Gül, Ahmet ; Inanc, Murat ; Ordi-Ros, Jose ; Ollier, William. / Transforming growth factor-β2 polymorphism and systemic lupus erythematosus. In: Journal of Rheumatology. 2002 ; Vol. 29, No. 6. pp. 1189-1191.
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