Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146

Allal Ouhtit, Rajiv L. Gaur, Zakaria Y. Abd Elmageed, Augusta Fernando, Rajesh Thouta, Alison K. Trappey, Mohamed E. Abdraboh, Hassan I. El-Sayyad, Prakash Rao, Madhwa G H Raj

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Abstract

CD146, also known as melanoma cell adhesion molecule or MCAM, is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis. CD146 promotes tumor progression of many cancers including melanoma and prostate. Strikingly, its expression is frequently lost in breast carcinoma cells, and it may act as a suppressor of breast cancer progression. While upstream mechanisms regulating CD146 are well documented, our understanding of the downstream molecular events underlying its mode of action remains to be elucidated. This review aims to focus on the progress in understanding the signaling mechanisms and the functional relevance of CD146, a multifaceted molecule, in cancer with particular emphasis on its role in inhibiting breast cancer progression.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1795
Issue number2
DOIs
Publication statusPublished - Apr 2009

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Keywords

  • Angiogenesis
  • Breast cancer
  • CD146
  • Signal transduction
  • Tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Ouhtit, A., Gaur, R. L., Abd Elmageed, Z. Y., Fernando, A., Thouta, R., Trappey, A. K., Abdraboh, M. E., El-Sayyad, H. I., Rao, P., & Raj, M. G. H. (2009). Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146. Biochimica et Biophysica Acta - Reviews on Cancer, 1795(2), 130-136. https://doi.org/10.1016/j.bbcan.2009.01.002