Abstract
Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
| Original language | English |
|---|---|
| Journal | Sultan Qaboos University Medical Journal |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - Jan 2014 |
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Keywords
- Antioxidants
- Diabetes mellitus
- Oxidative stress
- Tocotrienols
ASJC Scopus subject areas
- Medicine(all)
Cite this
Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats. / Matough, Fatmah A.; Budin, Siti B.; Hamid, Zariyantey A.; Abdul-Rahman, Mariati; Al-Wahaibi, Nasar; Mohammed, Jamaludine.
In: Sultan Qaboos University Medical Journal, Vol. 14, No. 1, 01.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats
AU - Matough, Fatmah A.
AU - Budin, Siti B.
AU - Hamid, Zariyantey A.
AU - Abdul-Rahman, Mariati
AU - Al-Wahaibi, Nasar
AU - Mohammed, Jamaludine
PY - 2014/1
Y1 - 2014/1
N2 - Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
AB - Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
KW - Antioxidants
KW - Diabetes mellitus
KW - Oxidative stress
KW - Tocotrienols
UR - http://www.scopus.com/inward/record.url?scp=84893380330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893380330&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84893380330
VL - 14
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
SN - 2075-051X
IS - 1
ER -