Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats

Fatmah A. Matough, Siti B. Budin, Zariyantey A. Hamid, Mariati Abdul-Rahman, Nasar Al-Wahaibi, Jamaludine Mohammed*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P

Original languageEnglish
JournalSultan Qaboos University Medical Journal
Volume14
Issue number1
Publication statusPublished - Jan 2014

Keywords

  • Antioxidants
  • Diabetes mellitus
  • Oxidative stress
  • Tocotrienols

ASJC Scopus subject areas

  • Medicine(all)

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