Abstract
Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
| Original language | English |
|---|---|
| Journal | Sultan Qaboos University Medical Journal |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - Jan 2014 |
Keywords
- Antioxidants
- Diabetes mellitus
- Oxidative stress
- Tocotrienols
ASJC Scopus subject areas
- Medicine(all)
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Matough, F. A., Budin, S. B., Hamid, Z. A., Abdul-Rahman, M., Al-Wahaibi, N., & Mohammed, J. (2014). Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats. Sultan Qaboos University Medical Journal, 14(1).