TY - JOUR
T1 - Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats
AU - Matough, Fatmah A.
AU - Budin, Siti B.
AU - Hamid, Zariyantey A.
AU - Abdul-Rahman, Mariati
AU - Al-Wahaibi, Nasar
AU - Mohammed, Jamaludine
PY - 2014/1
Y1 - 2014/1
N2 - Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
AB - Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P
KW - Antioxidants
KW - Diabetes mellitus
KW - Oxidative stress
KW - Tocotrienols
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M3 - Article
AN - SCOPUS:84893380330
VL - 14
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
SN - 2075-051X
IS - 1
ER -