Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats

Fatmah A. Matough, Siti B. Budin, Zariyantey A. Hamid, Mariati Abdul-Rahman, Nasar Al-Wahaibi, Jamaludine Mohammed

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P

Original languageEnglish
JournalSultan Qaboos University Medical Journal
Volume14
Issue number1
Publication statusPublished - Jan 2014

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Tocotrienols
Streptozocin
Blood Glucose
Fasting
Oxidative Stress
Erythrocyte Membrane
Leukocytes
Antioxidants
Erythrocytes
Biomarkers
DNA
palm oil

Keywords

  • Antioxidants
  • Diabetes mellitus
  • Oxidative stress
  • Tocotrienols

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matough, F. A., Budin, S. B., Hamid, Z. A., Abdul-Rahman, M., Al-Wahaibi, N., & Mohammed, J. (2014). Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats. Sultan Qaboos University Medical Journal, 14(1).

Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats. / Matough, Fatmah A.; Budin, Siti B.; Hamid, Zariyantey A.; Abdul-Rahman, Mariati; Al-Wahaibi, Nasar; Mohammed, Jamaludine.

In: Sultan Qaboos University Medical Journal, Vol. 14, No. 1, 01.2014.

Research output: Contribution to journalArticle

Matough, FA, Budin, SB, Hamid, ZA, Abdul-Rahman, M, Al-Wahaibi, N & Mohammed, J 2014, 'Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats', Sultan Qaboos University Medical Journal, vol. 14, no. 1.
Matough, Fatmah A. ; Budin, Siti B. ; Hamid, Zariyantey A. ; Abdul-Rahman, Mariati ; Al-Wahaibi, Nasar ; Mohammed, Jamaludine. / Tocotrienol-rich fraction from palm oil prevents oxidative damage in diabetic rats. In: Sultan Qaboos University Medical Journal. 2014 ; Vol. 14, No. 1.
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